Literature DB >> 11481304

Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France.

P Weber1, J Filipecki, E Bingen, F Fitoussi, G Goldfarb, J P Chauvin, C Reitz, H Portier.   

Abstract

Three hundred and three strains of group A streptococci (GAS) isolated from adults with pharyngitis were tested to evaluate their phenotype of resistance to macrolides-lincosamides and to search for macrolide resistance genes. MICs of clarithromycin were determined. The overall rate of resistance to both erythromycin and clarithromycin was 9.6%. Constitutive, inducible and M phenotypes of resistance were detected in 4.3, 2 and 3.3% of strains, respectively. All constitutive phenotypes harboured ermB genes, whereas inducible phenotypes had the ermTR gene and M phenotypes had the mefA gene. In France, the current resistance rate of GAS to erythromycin and clarithromycin remains low.

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Year:  2001        PMID： 11481304     DOI： 10.1093/jac/48.2.291

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  7 in total

1.  Genetic basis of erythromycin resistance in oral bacteria.

Authors:  A Villedieu; M L Diaz-Torres; A P Roberts; N Hunt; R McNab; D A Spratt; M Wilson; P Mullany
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

Review 2.  Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E).

Authors:  Corné H W Klaassen; Johan W Mouton
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

3.  Prevalence of Streptococcus invasive locus (sil) and its relationship with macrolide resistance among group A Streptococcus strains.

Authors:  Dewan Sakhawat Billal; Muneki Hotomi; Jun Shimada; Keiji Fujihara; Kimiko Ubukata; Rinya Sugita; Noboru Yamanaka
Journal:  J Clin Microbiol       Date:  2008-02-20       Impact factor: 5.948

4.  Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area.

Authors:  Meredith E Hasenbein; John E Warner; Kathleen G Lambert; Sarah E Cole; Andrew B Onderdonk; Alexander J McAdam
Journal:  J Clin Microbiol       Date:  2004-04       Impact factor: 5.948

5.  Pharmacoepidemiological analysis of provincial differences between consumption of macrolides and rates of erythromycin resistance among Streptococcus pyogenes isolates in Spain.

Authors:  C García-Rey; L Aguilar; F Baquero; J Casal; J E Martín
Journal:  J Clin Microbiol       Date:  2002-08       Impact factor: 5.948

6.  Antibiotic resistant beta-hemolytic streptococci.

Authors:  Charmaine A C Lloyd; Swarna E Jacob; Thangam Menon
Journal:  Indian J Pediatr       Date:  2007-12       Impact factor: 1.967

7.  Macrolide- and telithromycin-resistant Streptococcus pyogenes, Belgium, 1999-2003.

Authors:  Surbhi Malhotra-Kumar; Christine Lammens; Sabine Chapelle; Monique Wijdooghe; Jasper Piessens; Koen Van Herck; Herman Goossens
Journal:  Emerg Infect Dis       Date:  2005-06       Impact factor: 6.883
  7 in total

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