Literature DB >> 11479366

CFTR: interacting with everything?

K Kunzelmann1.   

Abstract

More than 1,300 different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) are the cause for cystic fibrosis. CFTR is in charge of proper secretion and absorption of electrolytes, and thus the disease is characterized by defective epithelial Cl(-) secretion and enhanced Na(+) absorption. Recent studies show that CFTR interacts with other proteins via PDZ domains.

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Year:  2001        PMID： 11479366     DOI： 10.1152/physiologyonline.2001.16.4.167

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  39 in total

1.  CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation.

Authors:  Torsten H Schroeder; Martin M Lee; Patrick W Yacono; Carolyn L Cannon; A Alev Gerçeker; David E Golan; Gerald B Pier
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-07       Impact factor: 11.205

Review 2.  Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis.

Authors:  Paul M Quinton
Journal:  Am J Physiol Cell Physiol       Date:  2010-10-06       Impact factor: 4.249

3.  Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect.

Authors:  Michael A Russo; Christoph Hogenauer; Stephen W Coates; Carol A Santa Ana; Jack L Porter; Randall L Rosenblatt; Michael Emmett; John S Fordtran
Journal:  J Clin Invest       Date:  2003-07       Impact factor: 14.808

Review 4.  Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

Authors:  Min Goo Lee; Ehud Ohana; Hyun Woo Park; Dongki Yang; Shmuel Muallem
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

Review 5.  Molecular diversity and regulation of renal potassium channels.

Authors:  Steven C Hebert; Gary Desir; Gerhard Giebisch; Wenhui Wang
Journal:  Physiol Rev       Date:  2005-01       Impact factor: 37.312

Review 6.  CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners.

Authors:  Chunying Li; Anjaparavanda P Naren
Journal:  Integr Biol (Camb)       Date:  2010-03-05       Impact factor: 2.192

7.  Transepithelial bicarbonate secretion: lessons from the pancreas.

Authors:  Hyun Woo Park; Min Goo Lee
Journal:  Cold Spring Harb Perspect Med       Date:  2012-10-01       Impact factor: 6.915

8.  Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA.

Authors:  Joydeep Aoun; Mikio Hayashi; Irshad Ali Sheikh; Paramita Sarkar; Tultul Saha; Priyanka Ghosh; Rajsekhar Bhowmick; Dipanjan Ghosh; Tanaya Chatterjee; Pinak Chakrabarti; Manoj K Chakrabarti; Kazi Mirajul Hoque
Journal:  J Biol Chem       Date:  2016-10-31       Impact factor: 5.157

9.  Light and alcohol evoked electro-oculograms in cystic fibrosis.

Authors:  Paul A Constable; John G Lawrenson; Geoffrey B Arden
Journal:  Doc Ophthalmol       Date:  2006-10-05       Impact factor: 2.379

10.  Bestrophin expression and function in the human pancreatic duct cell line, CFPAC-1.

Authors:  Laura L Marsey; John P Winpenny
Journal:  J Physiol       Date:  2009-02-23       Impact factor: 5.182
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