Literature DB >> 11479122

Combinatorial alanine-scanning.

K L Morrison1, G A Weiss.   

Abstract

Combinatorial libraries of alanine-substituted proteins can be used to rapidly identify residues important for protein function, stability and shape. Each alanine substitution examines the contribution of an individual amino acid sidechain to the functionality of the protein. The recently described method of shotgun scanning uses phage-displayed libraries of alanine-substituted proteins for high-throughput analysis.

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Year:  2001        PMID： 11479122     DOI： 10.1016/s1367-5931(00)00206-4

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  112 in total

1.  Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.

Authors:  Shalom D Goldberg; William Iannuccilli; Tuan Nguyen; Jingyue Ju; Virginia W Cornish
Journal:  Protein Sci       Date:  2003-08       Impact factor: 6.725

2.  Role of conserved glycine in zinc-dependent medium chain dehydrogenase/reductase superfamily.

Authors:  Manish Kumar Tiwari; Raushan Kumar Singh; Ranjitha Singh; Marimuthu Jeya; Huimin Zhao; Jung-Kul Lee
Journal:  J Biol Chem       Date:  2012-04-12       Impact factor: 5.157

3.  Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.

Authors:  N G Brown; T Palzkill
Journal:  Protein Eng Des Sel       Date:  2010-03-22       Impact factor: 1.650

4.  Site-directed mutagenesis of HgcA and HgcB reveals amino acid residues important for mercury methylation.

Authors:  Steven D Smith; Romain Bridou; Alexander Johs; Jerry M Parks; Dwayne A Elias; Richard A Hurt; Steven D Brown; Mircea Podar; Judy D Wall
Journal:  Appl Environ Microbiol       Date:  2015-02-27       Impact factor: 4.792

5.  A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection.

Authors:  Jonathan R Lai; Michael A Fischbach; David R Liu; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

Review 6.  Computational prediction of protein hot spot residues.

Authors:  John Kenneth Morrow; Shuxing Zhang
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

7.  Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces.

Authors:  Surendra S Negi; Werner Braun
Journal:  J Mol Model       Date:  2007-09-09       Impact factor: 1.810

8.  Detection of peptide-binding sites on protein surfaces: the first step toward the modeling and targeting of peptide-mediated interactions.

Authors:  Assaf Lavi; Chi Ho Ngan; Dana Movshovitz-Attias; Tanggis Bohnuud; Christine Yueh; Dmitri Beglov; Ora Schueler-Furman; Dima Kozakov
Journal:  Proteins       Date:  2013-10-17

9.  Molecular and conformational basis of a specific and high-affinity interaction between AlbA and albicidin phytotoxin.

Authors:  Li-Xing Weng; Lian-Hui Wang; Jin-Ling Xu; Ji-En Wu; Qi Li; Lian-Hui Zhang
Journal:  Appl Environ Microbiol       Date:  2005-03       Impact factor: 4.792

10.  Phage display of functional, full-length human and viral membrane proteins.

Authors:  Sudipta Majumdar; Agnes Hajduczki; Aaron S Mendez; Gregory A Weiss
Journal:  Bioorg Med Chem Lett       Date:  2008-07-17       Impact factor: 2.823
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