B Yu1, K Chen, J Mao. 1. Xiyuan Hospital, China Academy of TCM, Beijing 100091.
Abstract
OBJECTIVE: To explore the clinical effectiveness of concentrated Xuefu Zhuyu Pill (CXZP) on restenosis (RS) of coronary heart disease (CHD) after intracoronary stenting. METHODS:Eighty-four successful intracoronary stenting patients were randomly divided into conventional treatment group (control group, 41 cases) and conventional treatment plus CXZP group (treated group, 43 cases). The follow-up underwent for 6 months. Clinical symptom, change of blood stasis were observed. And occurrence of restenosis was estimated by ECG exercise treadmill testing, emission computed tomography (ECT) and coronary angiography (CAG). RESULTS: The symptoms of blood stasis of treated group improved in the follow-up significantly (P < 0.01), and the integral of blood stasis were decreased significantly in the treated group vs the conventional treatment group (P < 0.01). The recurrent angina pectoris rate of the treated group was lower than the conventional treatment group (P < 0.01). The 61.9% of 84 patients reexamined the CAG in the follow up, and the lower restenosis rate (25.8%) in the treated group than in the conventional treatment group (32.1%, P = 0.59). CONCLUSION: There is the trend that CXZP could prevent restenosis. Therefore, it is necessary to increase the cases for further study of CXZP on preventing restenosis.
RCT Entities:
OBJECTIVE: To explore the clinical effectiveness of concentrated Xuefu Zhuyu Pill (CXZP) on restenosis (RS) of coronary heart disease (CHD) after intracoronary stenting. METHODS: Eighty-four successful intracoronary stenting patients were randomly divided into conventional treatment group (control group, 41 cases) and conventional treatment plus CXZP group (treated group, 43 cases). The follow-up underwent for 6 months. Clinical symptom, change of blood stasis were observed. And occurrence of restenosis was estimated by ECG exercise treadmill testing, emission computed tomography (ECT) and coronary angiography (CAG). RESULTS: The symptoms of blood stasis of treated group improved in the follow-up significantly (P < 0.01), and the integral of blood stasis were decreased significantly in the treated group vs the conventional treatment group (P < 0.01). The recurrent angina pectoris rate of the treated group was lower than the conventional treatment group (P < 0.01). The 61.9% of 84 patients reexamined the CAG in the follow up, and the lower restenosis rate (25.8%) in the treated group than in the conventional treatment group (32.1%, P = 0.59). CONCLUSION: There is the trend that CXZP could prevent restenosis. Therefore, it is necessary to increase the cases for further study of CXZP on preventing restenosis.