OBJECTIVE: To assess the effects of supplementation with the carotenoids, beta-carotene or lycopene, at levels achievable within a diet rich in fruit and vegetables, on immune function in a group of free-living healthy elderly. DESIGN: A double-blind randomized placebo-controlled trial. T cell subsets and the expression of functionally associated cell surface molecules, quantified by flow cytometry, and lectin-stimulated lymphocyte proliferation, were compared before and following the treatment period. SUBJECTS:Fifty-eight subjects aged over 65 y were recruited; 52 were included in the final analysis. INTERVENTIONS: Participants received one placebo, one lycopene (13.3 mg) or one beta-carotene (8.2 mg) capsule daily for 12 weeks. RESULTS: No significant differences were observed in any of the parameters examined following either lycopene or beta-carotene supplementation. CONCLUSIONS: In well-nourished, free-living, healthy elderly individuals, supplementation with relatively low levels of beta-carotene or lycopene is not associated with either a beneficial or detrimental effects on several aspects of cell-mediated immunity.
RCT Entities:
OBJECTIVE: To assess the effects of supplementation with the carotenoids, beta-carotene or lycopene, at levels achievable within a diet rich in fruit and vegetables, on immune function in a group of free-living healthy elderly. DESIGN: A double-blind randomized placebo-controlled trial. T cell subsets and the expression of functionally associated cell surface molecules, quantified by flow cytometry, and lectin-stimulated lymphocyte proliferation, were compared before and following the treatment period. SUBJECTS: Fifty-eight subjects aged over 65 y were recruited; 52 were included in the final analysis. INTERVENTIONS:Participants received one placebo, one lycopene (13.3 mg) or one beta-carotene (8.2 mg) capsule daily for 12 weeks. RESULTS: No significant differences were observed in any of the parameters examined following either lycopene or beta-carotene supplementation. CONCLUSIONS: In well-nourished, free-living, healthy elderly individuals, supplementation with relatively low levels of beta-carotene or lycopene is not associated with either a beneficial or detrimental effects on several aspects of cell-mediated immunity.
Authors: Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G Simonetti; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2012-03-14
Authors: Mark Jesus M Magbanua; Ritu Roy; Eduardo V Sosa; Vivian Weinberg; Scott Federman; Michael D Mattie; Millie Hughes-Fulford; Jeff Simko; Katsuto Shinohara; Christopher M Haqq; Peter R Carroll; June M Chan Journal: PLoS One Date: 2011-09-01 Impact factor: 3.240
Authors: Nancy L Sheehan; Rolf P G van Heeswijk; Brian C Foster; Humayoun Akhtar; Neera Singhal; Isabelle Seguin; Lina DelBalso; Marc Bourbeau; Bobby M Chauhan; Mohammed-Rachid Boulassel; David M Burger; Richard G Lalonde; Donald William Cameron Journal: Molecules Date: 2012-01-12 Impact factor: 4.411