Literature DB >> 11477131

Molecular pathology of solid tumours: some practical suggestions for translating research into clinical practice.

I P Tomlinson1, M Ilyas.   

Abstract

"Molecular pathology" can be broadly defined as the use of genetic data, in addition to the standard pathological parameters, to optimise diagnosis and to indicate treatment and prognosis. The benefit to be gained from the exploitation of molecular techniques to provide additional information to aid patient management is potentially vast. Currently, molecular pathology is rarely used in clinical practice, although it is anticipated that it will eventually become a part of routine practice. However, incorporating molecular techniques into routine practice will not be straightforward because there are several issues to be resolved. Following on from a symposium held at the Royal College of Pathologists to discuss some of these issues, the establishment of a committee of molecular pathology is proposed to plan and coordinate the introduction of molecular pathology into routine clinical practice.

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Year:  2001        PMID: 11477131      PMCID: PMC1187067          DOI: 10.1136/mp.54.4.203

Source DB:  PubMed          Journal:  Mol Pathol        ISSN: 1366-8714


  11 in total

1.  Gene index analysis of the human genome estimates approximately 120,000 genes.

Authors:  F Liang; I Holt; G Pertea; S Karamycheva; S L Salzberg; J Quackenbush
Journal:  Nat Genet       Date:  2000-06       Impact factor: 38.330

2.  A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.

Authors:  M J Newport; C M Huxley; S Huston; C M Hawrylowicz; B A Oostra; R Williamson; M Levin
Journal:  N Engl J Med       Date:  1996-12-26       Impact factor: 91.245

3.  The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews.

Authors:  T Woodage; S M King; S Wacholder; P Hartge; J P Struewing; M McAdams; S J Laken; M A Tucker; L C Brody
Journal:  Nat Genet       Date:  1998-09       Impact factor: 38.330

Review 4.  Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors.

Authors:  G J Prud'homme
Journal:  J Gene Med       Date:  2000 Jul-Aug       Impact factor: 4.565

5.  Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

Authors:  L Steidler; W Hans; L Schotte; S Neirynck; F Obermeier; W Falk; W Fiers; E Remaut
Journal:  Science       Date:  2000-08-25       Impact factor: 47.728

Review 6.  The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil.

Authors:  R B Diasio; M R Johnson
Journal:  Pharmacology       Date:  2000-09       Impact factor: 2.547

7.  Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.

Authors:  P Lichtenstein; N V Holm; P K Verkasalo; A Iliadou; J Kaprio; M Koskenvuo; E Pukkala; A Skytthe; K Hemminki
Journal:  N Engl J Med       Date:  2000-07-13       Impact factor: 91.245

Review 8.  Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.

Authors:  C C Compton; L P Fielding; L J Burgart; B Conley; H S Cooper; S R Hamilton; M E Hammond; D E Henson; R V Hutter; R B Nagle; M L Nielsen; D J Sargent; C R Taylor; M Welton; C Willett
Journal:  Arch Pathol Lab Med       Date:  2000-07       Impact factor: 5.534

9.  Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.

Authors:  S J Laken; G M Petersen; S B Gruber; C Oddoux; H Ostrer; F M Giardiello; S R Hamilton; H Hampel; A Markowitz; D Klimstra; S Jhanwar; S Winawer; K Offit; M C Luce; K W Kinzler; B Vogelstein
Journal:  Nat Genet       Date:  1997-09       Impact factor: 38.330

10.  Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls.

Authors:  H Corominas; M Domènech; D González; C Diaz; M Roca; M A García-González; S Peña; M Baiget
Journal:  Am J Gastroenterol       Date:  2000-09       Impact factor: 10.864

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  1 in total

1.  Molecular pathology of solid tumours: translating research into clinical practice. Introduction and overview.

Authors:  I Tomlinson
Journal:  Mol Pathol       Date:  2001-08
  1 in total

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