Literature DB >> 11476887

Regulation of Na+ channel distribution in the nervous system.

S D Novakovic1, R M Eglen, J C Hunter.   

Abstract

An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.

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Year:  2001        PMID： 11476887     DOI： 10.1016/s0166-2236(00)01884-1

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  9 in total

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  9 in total

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