Literature DB >> 11476762

Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases.

A J Fox1, H J Patel, P J Barnes, M G Belvisi.   

Abstract

Elevated levels of nerve growth factor (NGF) have been detected in the bronchoalveolar lavage fluid of patients with asthma. However, the source of this enhanced mediator production is not known. Here, we investigate the production of NGF from a human airway epithelial cell line (A549). Under basal conditions, A549 cells generated NGF in a time-dependent fashion. However, basal release was significantly augmented in a concentration-dependent manner in cells treated with interleukin-1beta (IL-1beta) or tumour necrosis factor-alpha (TNF-alpha) and inhibited by dexamethasone. These data suggest that NGF released from structural cells may be an important target for the anti-inflammatory effects of steroids in asthma therapy.

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Year:  2001        PMID： 11476762     DOI： 10.1016/s0014-2999(01)01138-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

Review 1.  Neurotrophins in lung health and disease.

Authors:  Ys Prakash; Michael A Thompson; Lucas Meuchel; Christina M Pabelick; Carlos B Mantilla; Syed Zaidi; Richard J Martin
Journal:  Expert Rev Respir Med       Date:  2010-06       Impact factor: 3.772

2.  Role of nerve growth factor in ozone-induced neural responses in early postnatal airway development.

Authors:  Dawn D Hunter; Lynnsey A Carrell-Jacks; Tom P Batchelor; Richard D Dey
Journal:  Am J Respir Cell Mol Biol       Date:  2010-11-12       Impact factor: 6.914

3.  Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.

Authors:  Annette T Hastie; Wendy C Moore; Deborah A Meyers; Penny L Vestal; Huashi Li; Stephen P Peters; Eugene R Bleecker
Journal:  J Allergy Clin Immunol       Date:  2010-04-15       Impact factor: 10.793

4.  Diagnostic value of neurotrophin expression in malignant pleural effusions.

Authors:  Bernard C Duysinx; Astrid Paulus; Vincent Heinen; Delphine Nguyen; Monique Henket; Jean-Louis Corhay; Renaud Louis
Journal:  Exp Ther Med       Date:  2011-06-30       Impact factor: 2.447

5.  Ozone exposure initiates a sequential signaling cascade in airways involving interleukin-1beta release, nerve growth factor secretion, and substance P upregulation.

Authors:  Joshua S Barker; Zhongxin Wu; Dawn D Hunter; Richard D Dey
Journal:  J Toxicol Environ Health A       Date:  2015

6.  Staphylococcal enterotoxin B causes proliferation of sensory C-fibers and subsequent enhancement of neurogenic inflammation in rat skin.

Authors:  Mihoko Ohshima; Mio Miyake; Masanori Takeda; Michihiro Kamijima; Tatsuo Sakamoto
Journal:  J Infect Dis       Date:  2011-01-20       Impact factor: 5.226

7.  Human lung fibroblast response to NGF, IL-1beta, and dexamethsone.

Authors:  A Antonelli; G Lapucci; E Vigneti; Se Bonini; L Aloe
Journal:  Lung       Date:  2005 Sep-Oct       Impact factor: 2.584

8.  MiR-155 modulates the progression of neuropathic pain through targeting SGK3.

Authors:  Shaoxing Liu; Bo Zhu; Yan Sun; Xianfeng Xie
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

9.  Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.

Authors:  Herbert Riechelmann
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2004-12-28

Review 10.  Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.

Authors:  Frances C Shaffo; Ana Cristina Grodzki; Allison D Fryer; Pamela J Lein
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2018-06-28       Impact factor: 5.464
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