| Literature DB >> 11475908 |
M Silva1, A S Lara, C Q Leite, E I Ferreira.
Abstract
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11475908 DOI： 10.1002/1521-4184(200106)334:6<189::aid-ardp189>3.0.co;2-6
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751