Literature DB >> 11475439

Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins.

S Spitsin1, D C Hooper, T Mikheeva, H Koprowski.   

Abstract

Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.

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Year:  2001        PMID： 11475439     DOI： 10.1177/135245850100700305

Source DB:  PubMed          Journal:  Mult Scler        ISSN： 1352-4585            Impact factor:   6.312


  18 in total

1.  No evidence of increased oxidative degradation of urate to allantoin in the CSF and serum of patients with multiple sclerosis.

Authors:  Stefan Kastenbauer; Bernd C Kieseier; Bernhard F Becker
Journal:  J Neurol       Date:  2005-02-23       Impact factor: 4.849

2.  Uric acid protects against secondary damage after spinal cord injury.

Authors:  Gwen S Scott; Salvatore Cuzzocrea; Tiziana Genovese; Hilary Koprowski; D Craig Hooper
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-22       Impact factor: 11.205

Review 3.  Insight into rheumatological cause and effect through the use of Mendelian randomization.

Authors:  Philip C Robinson; Hyon K Choi; Ron Do; Tony R Merriman
Journal:  Nat Rev Rheumatol       Date:  2016-07-14       Impact factor: 20.543

4.  Importance in Neuroprotection.

Authors:  Antonis G Tsamaloukas
Journal:  Dtsch Arztebl Int       Date:  2017-07-24       Impact factor: 5.594

5.  Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.

Authors:  Gwen S Scott; Sergei V Spitsin; Rhonda B Kean; Tatiana Mikheeva; Hilary Koprowski; D Craig Hooper
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-25       Impact factor: 11.205

6.  The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.

Authors:  Peter Higgins; Jesse Dawson; Matthew Walters
Journal:  Cardiovasc Psychiatry Neurol       Date:  2009-11-04

7.  The treatment of multiple sclerosis with inosine.

Authors:  Clyde E Markowitz; Sergei Spitsin; Vanessa Zimmerman; Dina Jacobs; Jayaram K Udupa; D Craig Hooper; Hilary Koprowski
Journal:  J Altern Complement Med       Date:  2009-06       Impact factor: 2.579

8.  Mammalian mismatches in nucleotide metabolism: implications for xenotransplantation.

Authors:  Zain Khalpey; Ada H Y Yuen; Marialuisa Lavitrano; Christopher G A McGregor; Kameljit K Kalsi; Magdi H Yacoub; Ryszard T Smolenski
Journal:  Mol Cell Biochem       Date:  2007-07-27       Impact factor: 3.396

9.  Uric acid as a CNS antioxidant.

Authors:  Gene L Bowman; Jackilen Shannon; Balz Frei; Jeffrey A Kaye; Joseph F Quinn
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

10.  Plasma urate and risk of Parkinson's disease.

Authors:  M G Weisskopf; E O'Reilly; H Chen; M A Schwarzschild; A Ascherio
Journal:  Am J Epidemiol       Date:  2007-06-20       Impact factor: 4.897
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