Literature DB >> 11474030

Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India.

C Mani1, N Selvakumar, S Narayanan, P R Narayanan.   

Abstract

Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the rpoB gene were analyzed by DNA sequencing of 50 Mycobacterium tuberculosis clinical isolates (44 resistant and 6 sensitive) from various parts of India. Fifty-three mutations of 18 different kinds, 17 point mutations and one deletion, were observed in 43 of 44 resistant isolates. Three novel mutations and three new alleles within the RRDR, along with two novel mutations outside the RRDR, are reported in this study.

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Year:  2001        PMID： 11474030      PMCID： PMC88277          DOI： 10.1128/JCM.39.8.2987-2990.2001

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  22 in total

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Authors:  K Hirano; C Abe; M Takahashi
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Authors:  S Ramaswamy; J M Musser
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4.  Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.

Authors:  V Kapur; L L Li; S Iordanescu; M R Hamrick; A Wanger; B N Kreiswirth; J M Musser
Journal:  J Clin Microbiol       Date:  1994-04       Impact factor: 5.948

Review 5.  The rapid diagnosis of isoniazid and rifampicin resistance in Mycobacterium tuberculosis--a molecular story.

Authors:  F A Drobniewski; S M Wilson
Journal:  J Med Microbiol       Date:  1998-03       Impact factor: 2.472

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Journal:  J Clin Microbiol       Date:  1998-01       Impact factor: 5.948

7.  The rpoB gene of Mycobacterium tuberculosis.

Authors:  L P Miller; J T Crawford; T M Shinnick
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Journal:  Am J Respir Cell Mol Biol       Date:  1994-12       Impact factor: 6.914

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  49 in total

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5.  Evaluation of the GeneXpert MTB/RIF assay for rapid diagnosis of tuberculosis and detection of rifampin resistance in pulmonary and extrapulmonary specimens.

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Journal:  J Clin Microbiol       Date:  2004-12       Impact factor: 5.948

7.  Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan.

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8.  New multiplex PCR for rapid detection of isoniazid-resistant Mycobacterium tuberculosis clinical isolates.

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