OBJECTIVE: This report examines: 1) the magnitude of co-occurrence of threshold and subthreshold-level depression and anxiety in the community, and 2) the relationship between comorbidity and the diagnostic level of depression and anxiety and their clinical correlates. METHOD: A community sample of 591 subjects was interviewed prospectively five times across 15 years from the ages of 20-35. The diagnostic interview allowed the assignment of diagnoses according to DSM-III criteria and operational definitions of subthreshold syndromes. RESULTS: 1) Comorbidity between depression and anxiety was more frequent when one syndrome reached threshold level; 2) comorbidity at both the threshold and subthreshold diagnostic levels was associated with symptom severity, disability and treatment, whereas the diagnostic level was associated with disability and suicidal attempts. CONCLUSION: The systematic association between comorbidity across diagnostic threshold levels of anxiety and depression with clinical correlates suggests the importance of a more dimensional approach to their classification.
OBJECTIVE: This report examines: 1) the magnitude of co-occurrence of threshold and subthreshold-level depression and anxiety in the community, and 2) the relationship between comorbidity and the diagnostic level of depression and anxiety and their clinical correlates. METHOD: A community sample of 591 subjects was interviewed prospectively five times across 15 years from the ages of 20-35. The diagnostic interview allowed the assignment of diagnoses according to DSM-III criteria and operational definitions of subthreshold syndromes. RESULTS: 1) Comorbidity between depression and anxiety was more frequent when one syndrome reached threshold level; 2) comorbidity at both the threshold and subthreshold diagnostic levels was associated with symptom severity, disability and treatment, whereas the diagnostic level was associated with disability and suicidal attempts. CONCLUSION: The systematic association between comorbidity across diagnostic threshold levels of anxiety and depression with clinical correlates suggests the importance of a more dimensional approach to their classification.
Authors: Gretchen A Brenes; Jack M Guralnik; Jeff D Williamson; Linda P Fried; Crystal Simpson; Eleanor M Simonsick; Brenda W J H Penninx Journal: J Am Geriatr Soc Date: 2005-01 Impact factor: 5.562
Authors: Marianne L Seney; Zhiguang Huo; Kelly Cahill; Leon French; Rachel Puralewski; Joyce Zhang; Ryan W Logan; George Tseng; David A Lewis; Etienne Sibille Journal: Biol Psychiatry Date: 2018-02-19 Impact factor: 13.382
Authors: Kirsten M Fiest; John D Fisk; Scott B Patten; Helen Tremlett; Christina Wolfson; Sharon Warren; Kyla A McKay; Lindsay I Berrigan; Ruth Ann Marrie Journal: Int J MS Care Date: 2016 Mar-Apr
Authors: Daniel E Jimenez; Amy Begley; Stephen J Bartels; Margarita Alegría; Stephen B Thomas; Sandra C Quinn; Charles F Reynolds Journal: Am J Geriatr Psychiatry Date: 2014-08-07 Impact factor: 4.105