| Literature DB >> 11473437 |
S Boonphong1, P Kittakoop, M Isaka, D Pittayakhajonwut, M Tanticharoen, Y Thebtaranonth.
Abstract
Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC(50) values of 7 and 2 microg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 microg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 microg/mL).Entities:
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Year: 2001 PMID： 11473437 DOI： 10.1021/np000291p
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050