Literature DB >> 11473435

Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.

J Ishida1, H K Wang, M Oyama, M L Cosentino, C Q Hu, K H Lee.   

Abstract

Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC(50) and therapeutic index values of 0.037 microM and 210, respectively.

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Year:  2001        PMID： 11473435     DOI： 10.1021/np0101189

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium.

Authors:  H Aassila; M L Bourguet-Kondracki; S Rifai; A Fassouane; M Guyot
Journal:  Mar Biotechnol (NY)       Date:  2003 Mar-Apr       Impact factor: 3.619

2.  Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats.

Authors:  Christudas Sunil; Savarimuthu Ignacimuthu; Chidambaram Kumarappan
Journal:  J Nat Med       Date:  2011-06-18       Impact factor: 2.343

3.  Chemical transformation and biological studies of marine sesquiterpene (S)-(+)-curcuphenol and its analogs.

Authors:  Waseem Gul; Nicholas L Hammond; Muhammad Yousaf; Jiangnan Peng; Andy Holley; Mark T Hamann
Journal:  Biochim Biophys Acta       Date:  2007-07-24

4.  Dietary effects of harmine, a β-carboline alkaloid, on development, energy reserves and α-amylase activity of Plodia interpunctella Hübner (Lepidoptera: Pyralidae).

Authors:  Noureddin Bouayad; Kacem Rharrabe; Mostafa Lamhamdi; Naima Ghailani Nourouti; Fouad Sayah
Journal:  Saudi J Biol Sci       Date:  2010-12-15       Impact factor: 4.219

5.  In vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus.

Authors:  Mohammad-Taghi Moradi; Ali Karimi; Fatemeh Fotouhi; Soleiman Kheiri; Ali Torabi
Journal:  Avicenna J Phytomed       Date:  2017 Nov-Dec

Review 6.  The potential of plant systems to break the HIV-TB link.

Authors:  Peyman Habibi; Henry Daniell; Carlos Ricardo Soccol; Maria Fatima Grossi-de-Sa
Journal:  Plant Biotechnol J       Date:  2019-07-18       Impact factor: 9.803

7.  Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication.

Authors:  Xia Wang; Xue Xu; Yan Li; Xiuxiu Li; Weiyang Tao; Bohui Li; Yonghua Wang; Ling Yang
Journal:  Integr Biol (Camb)       Date:  2013-02       Impact factor: 2.192

Review 8.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

Review 9.  Plant-derived lignans as potential antiviral agents: a systematic review.

Authors:  Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T Deyrup; Hong-Jie Zhang
Journal:  Phytochem Rev       Date:  2021-05-31       Impact factor: 7.741

Review 10.  Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview.

Authors:  Kesava Rao V Kurapati; Venkata S Atluri; Thangavel Samikkannu; Gabriella Garcia; Madhavan P N Nair
Journal:  Front Microbiol       Date:  2016-01-12       Impact factor: 5.640
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