| Literature DB >> 11473426 |
N K Ishikawa1, Y Fukushi, K Yamaji, S Tahara, K Takahashi.
Abstract
Two new cuparene-type sesquiterpenes, enokipodins C (1) and D (2), were isolated from culture medium of an edible mushroom, Flammulina velutipes, along with enokipodins A (3) and B (4). The structures of 1 and 2 were determined using spectroscopic methods (HRMS, (1)H and (13)C, and 2D NMR). The absolute configuration of enokipodin C was determined from the observed (1)H NMR chemical shifts and NOEs in NOESY experiments after conversion into the corresponding esters with the chiral reagent 2-(2'-methoxy-1'-naphthyl)-3,4-dichlorobenzoic acid. All the metabolites showed antimicrobial activity against a fungus, Cladosporium herbarum, and Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus.Entities:
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Year: 2001 PMID： 11473426 DOI： 10.1021/np000593r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050