The foot formation stimulating peptide pedibin is also involved in patterning of the head in hydra.

Pedibin, a peptide of 21 amino acids, has been shown to stimulate foot formation in hydra, one of the simplest metazoan animals. The data presented here show that pedibin is synthesized as a precursor of 49 amino acids. A putative cleavage site precedes the peptide as purified from hydra tissue. The precursor, like pedibin, accelerates foot regeneration. Pedibin transcripts are concentrated in the foot region of hydra as expected, but are also present in the head region accumulating in the tentacle bases. The early appearance of pedibin transcripts during phases of cell fate specification like budding and regeneration implies that in hydra, pedibin plays an important role in patterning processes of foot and head. This is confirmed by the finding that pedibin also stimulates bud outgrowth.