| Literature DB >> 11470164 |
S Beer1, A B Simins, A Schuster, B Holzmann.
Abstract
A novel full-length cDNA was isolated from a murine T-cell lymphoma library that has an open reading frame encoding 381 amino acids. The predicted protein (termed SLY) contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes. Northern blot and in situ hybridization analysis showed a preferential expression in lymphoid tissues. The sly gene is located on the X-chromosome in close proximity to genes involved in various immune disorders. This is consistent with an additional role of SLY in immune pathology.Entities:
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Year: 2001 PMID： 11470164 DOI： 10.1016/s0167-4781(01)00242-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002