OBJECTIVES: Despite recent advances regarding the role of diabetes with respect to cartilage metabolism, epidemiologic data to quantify the role of diabetes in the development of osteoarthritis (OA) are sparse. METHODS: OA patterns were studied in 809 patients with knee or hip joint replacement due to OA. NIDDM was defined by a history of physician diagnosed diabetes or use of antihyperglycemics. RESULTS: Patients with NIDDM had more often bilateral OA (adjusted odds ratio (OR)=2.2; 95% confidence interval (CI): 0.8-6.4). No association between NIDDM and generalized OA (adjusted OR= 1.0; 95%CI: 0.5-1.9) was observed. CONCLUSIONS: Our results are consistent with the hypothesis that NIDDM might be a potentially important systemic risk factor for knee and hip OA, but chance cannot be ruled out as an alternative explanation.
OBJECTIVES: Despite recent advances regarding the role of diabetes with respect to cartilage metabolism, epidemiologic data to quantify the role of diabetes in the development of osteoarthritis (OA) are sparse. METHODS: OA patterns were studied in 809 patients with knee or hip joint replacement due to OA. NIDDM was defined by a history of physician diagnosed diabetes or use of antihyperglycemics. RESULTS:Patients with NIDDM had more often bilateral OA (adjusted odds ratio (OR)=2.2; 95% confidence interval (CI): 0.8-6.4). No association between NIDDM and generalized OA (adjusted OR= 1.0; 95%CI: 0.5-1.9) was observed. CONCLUSIONS: Our results are consistent with the hypothesis that NIDDM might be a potentially important systemic risk factor for knee and hip OA, but chance cannot be ruled out as an alternative explanation.
Authors: Sheri L Maddigan; David H Feeny; Sumit R Majumdar; Karen B Farris; Jeffrey A Johnson Journal: Am J Public Health Date: 2006-07-27 Impact factor: 9.308
Authors: Ida K Haugen; Vasan S Ramachandran; Devyani Misra; Tuhina Neogi; Jingbo Niu; Tianzhong Yang; Yuqing Zhang; David T Felson Journal: Ann Rheum Dis Date: 2013-09-18 Impact factor: 19.103
Authors: Susana C Rosa; Juliana Gonçalves; Fernando Judas; Ali Mobasheri; Celeste Lopes; Alexandrina F Mendes Journal: Arthritis Res Ther Date: 2009-06-02 Impact factor: 5.156