Literature DB >> 11468327

Increased serum levels of interleukin-18 in patients with multiple sclerosis.

F Nicoletti1, R Di Marco, K Mangano, F Patti, E Reggio, A Nicoletti, K Bendtzen, A Reggio.   

Abstract

Serum but not CSF concentrations of the interferon-gamma-inducing cytokine interleukin (IL)-18 were significantly augmented in patients with MS as compared to both healthy controls and patients with other neurologic diseases. Patients with MS with secondary chronic progressive disease had significantly higher serum levels than those with relapsing remitting MS. In the latter group, IL-18 levels were higher in patients with acute exacerbation as compared to those with stable disease.

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Year:  2001        PMID: 11468327     DOI: 10.1212/wnl.57.2.342

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  25 in total

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8.  Use of the VH6-1 gene segment to code for anti-interleukin-18 autoantibodies in multiple sclerosis.

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Review 9.  IL-18 in inflammatory and autoimmune disease.

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