OBJECTIVE: The aim of the study was to evaluate the change over time of cartilage defects, subchondral lesions and meniscal abnormalities of the knee using magnetic resonance (MR) imaging with a 2-year interval in patients with chronic knee pain. DESIGN: In the format of a prospective study of early osteoarthritis (OA), the signal knee (most painful at the inclusion in the study 1990) in 47 individuals, 25 women and 22 men (aged 41-57 years, median 50), with chronic knee pain, with or without radiographically determined knee OA, were examined using MR imaging on a 1.0 T imager with a 2-year interval (median 25 months, range 21-30). Cartilage defects, subchondral lesions and meniscal abnormalities were recorded and compared in blind between the examinations. RESULTS: Five new cartilage defects and eight subchondral lesions appeared during the 2-year interval. Seven defects and seven subchondral lesions disappeared during the same time. Thirty-two out of 93 cartilage defects (34%) and 19 out of 32 subchondral lesions (59%) displayed an increase or a decrease in size over time. A meniscal abnormality appeared in three locations, and disappeared in none. In 14 out of 54 locations (26%) with a meniscal abnormality an increase or a decrease of the abnormality was recorded over time and no abnormality decreased. CONCLUSIONS: After the 2 years of observation it was possible to register, using MR imaging, the appearance, increase, decrease and disappearance of cartilage defects, subchondral lesions and meniscal abnormalities in middle-aged people with chronic knee pain. This has to be considered in studies of the natural course of knee OA as well as in studies of the intraarticular effect of pharmacological treatment aiming at cartilage repair or protection.
OBJECTIVE: The aim of the study was to evaluate the change over time of cartilage defects, subchondral lesions and meniscal abnormalities of the knee using magnetic resonance (MR) imaging with a 2-year interval in patients with chronic knee pain. DESIGN: In the format of a prospective study of early osteoarthritis (OA), the signal knee (most painful at the inclusion in the study 1990) in 47 individuals, 25 women and 22 men (aged 41-57 years, median 50), with chronic knee pain, with or without radiographically determined knee OA, were examined using MR imaging on a 1.0 T imager with a 2-year interval (median 25 months, range 21-30). Cartilage defects, subchondral lesions and meniscal abnormalities were recorded and compared in blind between the examinations. RESULTS: Five new cartilage defects and eight subchondral lesions appeared during the 2-year interval. Seven defects and seven subchondral lesions disappeared during the same time. Thirty-two out of 93 cartilage defects (34%) and 19 out of 32 subchondral lesions (59%) displayed an increase or a decrease in size over time. A meniscal abnormality appeared in three locations, and disappeared in none. In 14 out of 54 locations (26%) with a meniscal abnormality an increase or a decrease of the abnormality was recorded over time and no abnormality decreased. CONCLUSIONS: After the 2 years of observation it was possible to register, using MR imaging, the appearance, increase, decrease and disappearance of cartilage defects, subchondral lesions and meniscal abnormalities in middle-aged people with chronic knee pain. This has to be considered in studies of the natural course of knee OA as well as in studies of the intraarticular effect of pharmacological treatment aiming at cartilage repair or protection.
Authors: D J Hunter; W Zhang; Philip G Conaghan; K Hirko; L Menashe; L Li; W M Reichmann; E Losina Journal: Osteoarthritis Cartilage Date: 2011-03-23 Impact factor: 6.576
Authors: Peter R Kornaat; Ruth Y T Ceulemans; Herman M Kroon; Naghmeh Riyazi; Margreet Kloppenburg; Wayne O Carter; Thasia G Woodworth; Johan L Bloem Journal: Skeletal Radiol Date: 2004-10-08 Impact factor: 2.199
Authors: Miranda L Davies-Tuck; Anita E Wluka; Andrew Forbes; Yuanyuan Wang; Dallas R English; Graham G Giles; Richard O'Sullivan; Flavia M Cicuttini Journal: Arthritis Res Ther Date: 2010-01-19 Impact factor: 5.156
Authors: Dennis S Meredith; Elena Losina; Gesa Neumann; Hiroshi Yoshioka; Philipp K Lang; Jeffrey N Katz Journal: BMC Musculoskelet Disord Date: 2009-10-29 Impact factor: 2.362
Authors: Miranda L Davies-Tuck; Fahad Hanna; Susan R Davis; Robin J Bell; Sonia L Davison; Anita E Wluka; Jenny Adams; Flavia M Cicuttini Journal: Arthritis Res Ther Date: 2009-12-04 Impact factor: 5.156