Literature DB >> 11466174

GHB: an important pharmacologic and clinical update.

M S Okun1, L A Boothby, R B Bartfield, P L Doering.   

Abstract

Gamma-hydroxybutyrate (GHB) intoxication is a significant cause of morbidity and mortality in patients taking the drug for recreational purposes. Due to the recent increase in emergency room visits, hospital admissions, and deaths, it has become necessary to re-examine the pharmacology, pharmacokinetics, pharmacodynamics, clinical manifestations, and potential adverse effects associated with GHB use. We present an important pharmacologic and clinical update on GHB.

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Year:  2001        PMID： 11466174

Source DB:  PubMed          Journal:  J Pharm Pharm Sci        ISSN： 1482-1826            Impact factor:   2.327


  16 in total

1.  Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation.

Authors:  Indranil Bhattacharya; Kathleen M K Boje
Journal:  J Pharmacokinet Pharmacodyn       Date:  2006-08-29       Impact factor: 2.745

2.  Rapid reversible coma with intravenous gamma-hydroxybutyrate in a moxifloxacin-treated patient.

Authors:  Gerd Koehler; Anika Haimann; Hermann Laferl; Christoph Wenisch
Journal:  Clin Drug Investig       Date:  2005       Impact factor: 2.859

3.  Brain uptake of the drug of abuse γ-hydroxybutyric acid in rats.

Authors:  Samuel A Roiko; Melanie A Felmlee; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2011-10-21       Impact factor: 3.922

4.  Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.

Authors:  Melanie A Felmlee; Samuel A Roiko; Bridget L Morse; Marilyn E Morris
Journal:  J Pharmacol Exp Ther       Date:  2010-03-09       Impact factor: 4.030

5.  The Drug of Abuse Gamma-Hydroxybutyric Acid Exhibits Tissue-Specific Nonlinear Distribution.

Authors:  Melanie A Felmlee; Bridget L Morse; Kristin E Follman; Marilyn E Morris
Journal:  AAPS J       Date:  2017-12-26       Impact factor: 4.009

6.  γ-Hydroxybutyric Acid (GHB) Pharmacokinetics and Pharmacodynamics: Semi-Mechanistic and Physiologically Relevant PK/PD Model.

Authors:  Rutwij A Dave; Kristin E Follman; Marilyn E Morris
Journal:  AAPS J       Date:  2017-06-26       Impact factor: 4.009

7.  Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: inhibition of active renal reabsorption as a potential therapeutic strategy.

Authors:  Melanie A Felmlee; Qi Wang; Dapeng Cui; Samuel A Roiko; Marilyn E Morris
Journal:  AAPS J       Date:  2010-05-12       Impact factor: 4.009

8.  Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study.

Authors:  Marilyn E Morris; Bridget L Morse; Gloria J Baciewicz; Matthew M Tessena; Nicole M Acquisto; David J Hutchinson; Robert Dicenzo
Journal:  J Clin Toxicol       Date:  2011-11-10

9.  Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses.

Authors:  Samuel A Roiko; Nisha Vijay; Melanie A Felmlee; Marilyn E Morris
Journal:  Pharm Res       Date:  2013-01-15       Impact factor: 4.200

Review 10.  Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid.

Authors:  Marilyn E Morris; Melanie A Felmlee
Journal:  AAPS J       Date:  2008-06-04       Impact factor: 4.009
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