Literature DB >> 11463313

Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.

B M Kim1, S J Bae, S M So, H T Yoo, S K Chang, J H Lee, J Kang.   

Abstract

[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.

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Year:  2001        PMID： 11463313     DOI： 10.1021/ol016147s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Syntheses of FDA Approved HIV Protease Inhibitors.

Authors:  Arun K Ghosh; Geoffrey Bilcer; Gary Schiltz
Journal:  Synthesis (Stuttg)       Date:  2001       Impact factor: 3.157

2.  Highly stereoselective methylene transfers onto butanediacetal-protected chiral non-racemic sulfinyl imines using S-ylide technology.

Authors:  David C Forbes; Sampada V Bettigeri; Susanna C Pischek
Journal:  Chem Commun (Camb)       Date:  2009-03-09       Impact factor: 6.222

3.  Regioselective synthesis of N-beta-hydroxyethylaziridines by the ring-opening reaction of epoxides with aziridine generated in situ.

Authors:  Ha Young Kim; Arindam Talukdar; Mark Cushman
Journal:  Org Lett       Date:  2006-03-16       Impact factor: 6.005

4.  [(2R,3R)-3-(4-Nitro-phen-yl)aziridin-2-yl]methanol monohydrate.

Authors:  V Gaumet; C Denis; F Leal; M Madesclaire; V P Zaitsev
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-18
  4 in total

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