Literature DB >> 11460590

New concepts in pathogenesis and treatment of diabetic retinopathy.

J Spranger1, A F Pfeiffer.   

Abstract

Retinal neovascularization is a major feature of proliferative diabetic retinopathy, which represents a major public health problem, being responsible for more irreversible blindness in persons of middle and older age than any other pathology. The societal burden of ocular neovascularization has prompted extensive research into its mechanisms. The aim of this review will be to briefly summarize the current knowledge regarding the clinical and laboratory findings of diabetic retinopathy. From an investigational view, studies of ocular neovascularization provide important informations, often permitting real-time, serial observations of neovascularization in vivo. This allows investigators to analyse the relevance of specific pathogenic concepts regarding the mechanisms of angiogenesis in vivo. This review will additionally describe current concepts regarding the pathogenesis and treatment of diabetic retinopathy.

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Year:  2001        PMID： 11460590     DOI： 10.1055/s-2001-18601

Source DB:  PubMed          Journal:  Exp Clin Endocrinol Diabetes        ISSN： 0947-7349            Impact factor:   2.949


  23 in total

1.  Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells.

Authors:  Yagna P R Jarajapu; Sergio Caballero; Amrisha Verma; Takahiko Nakagawa; Margaret C Lo; Qiuhong Li; Maria B Grant
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-07-07       Impact factor: 4.799

2.  Prevention of retinal capillary basement membrane thickening in diabetic dogs by a non-steroidal anti-inflammatory drug.

Authors:  T A Gardiner; H R Anderson; T Degenhardt; S R Thorpe; J W Baynes; D B Archer; A W Stitt
Journal:  Diabetologia       Date:  2003-07-12       Impact factor: 10.122

3.  Nerve growth factor in diabetic retinopathy: beyond neurons.

Authors:  Barbara A Mysona; Ahmed Y Shanab; Sally L Elshaer; Azza B El-Remessy
Journal:  Expert Rev Ophthalmol       Date:  2014-04

4.  Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.

Authors:  Brian J Raisler; Kenneth I Berns; Maria B Grant; Denis Beliaev; William W Hauswirth
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-18       Impact factor: 11.205

5.  Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression.

Authors:  Akiko Higuchi; Koji Ohashi; Shinji Kihara; Kenneth Walsh; Noriyuki Ouchi
Journal:  Circ Res       Date:  2009-04-02       Impact factor: 17.367

6.  Towards optimal filtering of "standard" multifocal electroretinogram (mfERG) recordings: findings in normal and diabetic subjects.

Authors:  Y Han; M A Bearse; M E Schneck; S Barez; C Jacobsen; A J Adams
Journal:  Br J Ophthalmol       Date:  2004-04       Impact factor: 4.638

7.  Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy.

Authors:  Ahmed M Abu El-Asrar; Ghulam Mohammad; Mohd Imtiaz Nawaz; Mohammad Mairaj Siddiquei; Kathleen Van den Eynde; Ahmed Mousa; Gert De Hertogh; Ghislain Opdenakker
Journal:  PLoS One       Date:  2013-12-31       Impact factor: 3.240

8.  S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis.

Authors:  Ahmed M Abu El-Asrar; Mohd Imtiaz Nawaz; Gert De Hertogh; Kaiser Alam; Mohammad Mairaj Siddiquei; Kathleen Van den Eynde; Ahmed Mousa; Ghulam Mohammad; Karel Geboes; Ghislain Opdenakker
Journal:  Mol Vis       Date:  2014-09-10       Impact factor: 2.367

9.  High-mobility group box-1 and endothelial cell angiogenic markers in the vitreous from patients with proliferative diabetic retinopathy.

Authors:  Ahmed M Abu El-Asrar; Mohd Imtiaz Nawaz; Dustan Kangave; Marwan Abouammoh; Ghulam Mohammad
Journal:  Mediators Inflamm       Date:  2012-10-16       Impact factor: 4.711

10.  Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy.

Authors:  Ahmed M Abu El-Asrar; Ghulam Mohammad; Gert De Hertogh; Mohd Imtiaz Nawaz; Kathleen Van Den Eynde; Mohammad Mairaj Siddiquei; Sofie Struyf; Ghislain Opdenakker; Karel Geboes
Journal:  PLoS One       Date:  2013-06-07       Impact factor: 3.240
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