| Literature DB >> 11459668 |
N S Cutshall1, R Ursino, K A Kucera, J Latham, N C Ihle.
Abstract
A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.Entities:
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Year: 2001 PMID： 11459668 DOI： 10.1016/s0960-894x(01)00326-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823