| Literature DB >> 11459666 |
M Patel1, R J McHugh, B C Cordova, R M Klabe, L T Bacheler, S Erickson-Viitanen, J D Rodgers.
Abstract
A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.Entities:
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Year: 2001 PMID： 11459666 DOI： 10.1016/s0960-894x(01)00331-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823