| Literature DB >> 11459658 |
R A Porter1, W N Chan, S Coulton, A Johns, M S Hadley, K Widdowson, J C Jerman, S J Brough, M Coldwell, D Smart, F Jewitt, P Jeffrey, N Austin.
Abstract
This communication reports SARs for the first orexin-1 receptor antagonist series of 1-aryl-3-quinolin-4-yl and 1-aryl-3-naphthyridin-4-yl ureas. One of these compounds, 31 (SB-334867), has excellent selectivity for the orexin-1 receptor, blood-brain barrier permeability and shows in vivo activity following ip dosing.Entities:
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Year: 2001 PMID： 11459658 DOI： 10.1016/s0960-894x(01)00343-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823