Literature DB >> 11458999

Hyperhomocysteinemia in dementia.

F Leblhuber1, J Walli, E Artner-Dworzak, K Vrecko, B Widner, G Reibnegger, D Fuchs.   

Abstract

Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.

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Year:  2000        PMID： 11458999     DOI： 10.1007/s007020070010

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  16 in total

1.  Polyneuropathy and dementia in old age: common inflammatory and vascular parameters.

Authors:  Friedrich Leblhuber; Katharina Schroecksnadel; Margit Beran-Praher; Herbert Haller; Kostja Steiner; Dietmar Fuchs
Journal:  J Neural Transm (Vienna)       Date:  2011-02-01       Impact factor: 3.575

2.  Asymmetric dimethylarginine is not elevated in exfoliation syndrome but symmetric dimethylarginine is related to exfoliative glaucoma.

Authors:  Hillevi Blomster; Tuomo Puustjärvi; Matti Kontkanen; Pirjo Valtonen; Markku Teräsvirta; Hannu Uusitalo
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2007-02       Impact factor: 3.117

3.  Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia.

Authors:  Francieli M Stefanello; Renata Franzon; Bárbara Tagliari; Clovis Wannmacher; Moacir Wajner; Angela T S Wyse
Journal:  Metab Brain Dis       Date:  2005-06       Impact factor: 3.584

4.  Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study.

Authors:  H Frieling; B Röschke; J Kornhuber; J Wilhelm; K D Römer; B Gruss; D Bönsch; T Hillemacher; M de Zwaan; G E Jacoby; S Bleich
Journal:  J Neural Transm (Vienna)       Date:  2005-11       Impact factor: 3.575

5.  Homocysteine but not neopterin declines in demented patients on B vitamins.

Authors:  B Frick; B Gruber; K Schroecksnadel; F Leblhuber; D Fuchs
Journal:  J Neural Transm (Vienna)       Date:  2006-09-21       Impact factor: 3.575

6.  Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma.

Authors:  Ozgül Altintaş; Hale Maral; Nurşen Yüksel; V Levent Karabaş; Meltem O Dillioğlugil; Yusuf Cağlar
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2005-02-02       Impact factor: 3.117

7.  Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet.

Authors:  Jia-Min Zhuo; Domenico Praticò
Journal:  Exp Gerontol       Date:  2009-12-11       Impact factor: 4.032

8.  One-carbon metabolism and Alzheimer's disease: focus on epigenetics.

Authors:  Fabio Coppedè
Journal:  Curr Genomics       Date:  2010-06       Impact factor: 2.236

Review 9.  Treating vascular risk factors and maintaining vascular health: is this the way towards successful cognitive ageing and preventing cognitive decline?

Authors:  K Alagiakrishnan; P McCracken; H Feldman
Journal:  Postgrad Med J       Date:  2006-02       Impact factor: 2.401

10.  Serum Homocysteine, Dehydroepiandrosterone Sulphate and Lipoprotein (a) in Alzheimer's Disease and Vascular Dementia.

Authors:  Lopamudra Ray; Vineet Kumar Khemka; Prajna Behera; Kausik Bandyopadhyay; Sandip Pal; Keya Pal; Debasis Basu; Sasanka Chakrabarti
Journal:  Aging Dis       Date:  2013-03-07       Impact factor: 6.745
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