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Literature DB >> 114570

The effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients.

Abstract

The effect of exogenous prednisone on serum thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) concentrations was investigated in four patients with non-functioning thyroid glands receiving T4 replacement therapy. Orally administered prednisone, in a dose of 20 mg each day for nine days, resulted in a significant decrease in mean serum TSH levels (p less than 0.01) without significant changes in levels of serum T4, T3, and thyroxine binding globulin (TBG). These findings suggest an inhibitory action of relatively low pharmacologic doses of prednisone on TSH release without changes in circulating thyroid hormone concentrations or inhibition of the peripheral conversion of T4 to T3.

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Year: 1978 PMID： 114570 DOI： 10.1007/BF03350367

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

15 in total

1. EFFECT OF CORTISONE ON THE PERIPHERAL DEGRADATION OF 131-I-THYROXINE.

Authors: B BLOMSTEDT; J EINHORN
Journal: J Clin Endocrinol Metab Date: 1965-02 Impact factor: 5.958

2. The influence of ACTH, cortisone, and hydrocortisone on the distribution and peripheral metabolism of thyroxine.

Authors: S H INGBAR; N FREINKEL
Journal: J Clin Invest Date: 1955-09 Impact factor: 14.808

3. Effect of prednisone on thyroxine-binding proteins.

Authors: J H Oppenheimer; S C Werner
Journal: J Clin Endocrinol Metab Date: 1966-07 Impact factor: 5.958

4. Effect of single dose dexamethasone on the concentration of serum triiodothyronine in man.

Authors: D S Duick; D W Warren; J T Nicoloff; C L Otis; M S Croxson
Journal: J Clin Endocrinol Metab Date: 1974-12 Impact factor: 5.958

5. An improved radioimmunoassay of triiodothyronine in serum: its application to clinical and physiological studies.

Authors: I J Chopra; R S Ho; R Lam
Journal: J Lab Clin Med Date: 1972-11

6. Direct evaluation of pituitary thyrotopin reserve utilizing synthetic thyrotopin releasing hormone.

Authors: E D Haigler; J A Pittman; J M Hershman; C M Baugh
Journal: J Clin Endocrinol Metab Date: 1971-10 Impact factor: 5.958

7. Radioimmunoassay for serum thyroxine-binding globulin: results in normal subjects and in patients with hepatocellular carcinoma.

Authors: M C Gershengorn; P R Larsen; J Robbins
Journal: J Clin Endocrinol Metab Date: 1976-05 Impact factor: 5.958

The effect of prednisone on serum thyrotropin, thyroxine and triiodothyronine concentrations in hypothyroid patients.

1. EFFECT OF CORTISONE ON THE PERIPHERAL DEGRADATION OF 131-I-THYROXINE.

2. The influence of ACTH, cortisone, and hydrocortisone on the distribution and peripheral metabolism of thyroxine.

3. Effect of prednisone on thyroxine-binding proteins.

4. Effect of single dose dexamethasone on the concentration of serum triiodothyronine in man.

5. An improved radioimmunoassay of triiodothyronine in serum: its application to clinical and physiological studies.

6. Direct evaluation of pituitary thyrotopin reserve utilizing synthetic thyrotopin releasing hormone.

7. Radioimmunoassay for serum thyroxine-binding globulin: results in normal subjects and in patients with hepatocellular carcinoma.

8. The effect of glucocorticoids on thyrotropin secretion.

9. The role of glucocorticoids in the regulation of thyroid function in man.

10. Effect of dexamethasone on thyroid hormone response to TSH.

1. Hypothyroidism in patients with asthma and major depressive disorder.

2. Autoimmune Hypothyroidism As a Predictor of Mortality in Chronic Hypersensitivity Pneumonitis.

3. Does TSH Reliably Detect Hypothyroid Patients?