OBJECTIVE: Tobacco use is the most prominent cause of respiratory cancers. Little is known, however, about the influence of smoking on hematolymphopoietic malignancies. To evaluate this relation, a population-based case-control study was carried out in 12 areas of Italy. METHODS: Detailed interviews on tobacco smoking habits were administered to 1450 non-Hodgkin's lymphoma (NHL), 365 Hodgkin's disease (HD), 270 multiple myeloma (MM), and 649 leukemia (LEU) patients occurring from 1990 to 1993, and 1779 population controls. RESULTS: We found a slightly increased risk for NHL in smokers (odds ratio 1.2, 95% confidence interval 1.0-1.4 for ever smokers), but a consistent positive association was shown only for follicular NHL. In this subtype, a significant excess risk was observed for ever versus never smokers, after adjustment for gender, age, geographic residence, education, and respondent (OR = 1.8, 95%, CI 1.3-2.7), with a positive exposure-response gradient for smoking duration (p < 0.01). The risk for follicular NHL was significantly elevated only among women, with ever smokers showing OR = 2.3 (CI 1.4-3.8), while for men we found OR = 1.3 (CI 0.69-2.3). No major differences were shown according to age. Female subjects also showed significant positive exposure-response trends for duration. CONCLUSION: Cigarette smoking could be a risk factor for follicular NHL among women. For HD, MM, or LEU, no clear association was observed.
OBJECTIVE:Tobacco use is the most prominent cause of respiratory cancers. Little is known, however, about the influence of smoking on hematolymphopoietic malignancies. To evaluate this relation, a population-based case-control study was carried out in 12 areas of Italy. METHODS: Detailed interviews on tobacco smoking habits were administered to 1450 non-Hodgkin's lymphoma (NHL), 365 Hodgkin's disease (HD), 270 multiple myeloma (MM), and 649 leukemia (LEU) patients occurring from 1990 to 1993, and 1779 population controls. RESULTS: We found a slightly increased risk for NHL in smokers (odds ratio 1.2, 95% confidence interval 1.0-1.4 for ever smokers), but a consistent positive association was shown only for follicular NHL. In this subtype, a significant excess risk was observed for ever versus never smokers, after adjustment for gender, age, geographic residence, education, and respondent (OR = 1.8, 95%, CI 1.3-2.7), with a positive exposure-response gradient for smoking duration (p < 0.01). The risk for follicular NHL was significantly elevated only among women, with ever smokers showing OR = 2.3 (CI 1.4-3.8), while for men we found OR = 1.3 (CI 0.69-2.3). No major differences were shown according to age. Female subjects also showed significant positive exposure-response trends for duration. CONCLUSION: Cigarette smoking could be a risk factor for follicular NHL among women. For HD, MM, or LEU, no clear association was observed.
Authors: Cindy M Chang; Jane C Schroeder; Andrew F Olshan; Cherie H Dunphy; Wen-Yi Huang; Ralph S Baric; Kathleen Conway; James R Cerhan; Charles F Lynch; Nathaniel Rothman; Kenneth P Cantor; Aaron Blair Journal: Cancer Causes Control Date: 2010-03-16 Impact factor: 2.506
Authors: M Kamper-Jørgensen; K Rostgaard; S L Glaser; S H Zahm; W Cozen; K E Smedby; S Sanjosé; E T Chang; T Zheng; C La Vecchia; D Serraino; A Monnereau; E V Kane; L Miligi; P Vineis; J J Spinelli; J R McLaughlin; P Pahwa; J A Dosman; M Vornanen; L Foretova; M Maynadie; A Staines; N Becker; A Nieters; P Brennan; P Boffetta; P Cocco; H Hjalgrim Journal: Ann Oncol Date: 2013-06-19 Impact factor: 32.976
Authors: Yani Lu; Sophia S Wang; Peggy Reynolds; Ellen T Chang; Huiyan Ma; Jane Sullivan-Halley; Christina A Clarke; Leslie Bernstein Journal: Am J Epidemiol Date: 2011-07-18 Impact factor: 4.897
Authors: Cindy M Chang; Sophia S Wang; Bhavana J Dave; Smrati Jain; Mohammad A Vasef; Dennis D Weisenburger; Wendy Cozen; Scott Davis; Richard K Severson; Charles F Lynch; Nathaniel Rothman; James R Cerhan; Patricia Hartge; Lindsay M Morton Journal: Int J Cancer Date: 2010-11-23 Impact factor: 7.396
Authors: Curt T DellaValle; Nicole C Deziel; Rena R Jones; Joanne S Colt; Anneclaire J De Roos; James R Cerhan; Wendy Cozen; Richard K Severson; Abigail R Flory; Lindsay M Morton; Mary H Ward Journal: Cancer Causes Control Date: 2015-11-16 Impact factor: 2.506
Authors: Briseis A Kilfoy; Tongzhang Zheng; Qing Lan; Xuesong Han; Theodore Holford; David W Hein; Qin Qin; Brian Leaderer; Lindsay M Morton; Meredith Yeager; Peter Boyle; Ping Zhao; Stephen Chanock; Nathaniel Rothman; Yawei Zhang Journal: Cancer Causes Control Date: 2009-10-07 Impact factor: 2.506
Authors: H Besson; P Brennan; N Becker; S De Sanjosé; A Nieters; R Font; M Maynadié; L Foretova; P L Cocco; A Staines; M Vornanen; P Boffetta Journal: Br J Cancer Date: 2006-07-04 Impact factor: 7.640
Authors: K A Mundt; L D Dell; P Boffetta; E M Beckett; H N Lynch; V J Desai; C K Lin; W J Thompson Journal: BMC Cancer Date: 2021-03-06 Impact factor: 4.430
Authors: L M Morton; T R Holford; B Leaderer; P Boyle; S H Zahm; Y Zhang; S Flynn; G Tallini; B Zhang; P H Owens; T Zheng Journal: Br J Cancer Date: 2003-12-01 Impact factor: 7.640