Literature DB >> 11454473

Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.

T Maruyama1, M Asada, T Shiraishi, A Ishida, H Egashira, H Yoshida, T Maruyama1, S Ohuchida, H Nakai, K Kondo, M Toda.   

Abstract

A series of 3,7-dithiaPGE(1) analogues 3, 4, 11, 16 and 19 were identified as highly selective EP4-receptor agonists starting from the chemical modification of 7-thiaPGE(1) analogue 1. EP4-receptor selectivity and agonist activity were maximized in 3 and 4.

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Year:  2001        PMID： 11454473     DOI： 10.1016/s0960-894x(01)00364-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.

Authors:  Hidetoshi Taniguchi; Christoph Anacker; Qian Wang; Katrin Andreasson
Journal:  Exp Neurol       Date:  2014-02-20       Impact factor: 5.330

2.  Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.

Authors:  Alexandra Boussommier-Calleja; Jacques Bertrand; David F Woodward; C Ross Ethier; W Daniel Stamer; Darryl R Overby
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-08-24       Impact factor: 4.799

3.  Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.

Authors:  Xibin Liang; Lu Lin; Nathaniel S Woodling; Qian Wang; Christoph Anacker; Tingting Pan; Milton Merchant; Katrin Andreasson
Journal:  J Clin Invest       Date:  2011-10-03       Impact factor: 14.808
  3 in total

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