Literature DB >> 11454472

Design and synthesis of a highly selective EP2-receptor agonist.

K Tani1, A Naganawa, A Ishida, H Egashira, K Sagawa, H Harada, M Ogawa, T Maruyama, S Ohuchida, H Nakai, K Kondo, M Toda.   

Abstract

EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11454472     DOI： 10.1016/s0960-894x(01)00359-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Discovery of G Protein-Biased EP2 Receptor Agonists.

Authors:  Seiji Ogawa; Toshihide Watanabe; Isamu Sugimoto; Kazumi Moriyuki; Yoshikazu Goto; Shinsaku Yamane; Akio Watanabe; Kazuma Tsuboi; Atsushi Kinoshita; Hideo Kigoshi; Kousuke Tani; Toru Maruyama
Journal:  ACS Med Chem Lett       Date:  2016-01-04       Impact factor: 4.345

2.  Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor.

Authors:  K M Faisal Khan; Poonam Kothari; Baoheng Du; Andrew J Dannenberg; Domenick J Falcone
Journal:  J Immunol       Date:  2012-01-06       Impact factor: 5.422

3.  Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

Authors:  Deborah L Clarke; Maria G Belvisi; Matthew C Catley; Magdi H Yacoub; Robert Newton; Mark A Giembycz
Journal:  Br J Pharmacol       Date:  2004-03-15       Impact factor: 8.739

Review 4.  Prostanoid receptor EP2 as a therapeutic target.

Authors:  Thota Ganesh
Journal:  J Med Chem       Date:  2013-12-04       Impact factor: 7.446

5.  Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.

Authors:  Juan A Giménez-Bastida; William E Boeglin; Olivier Boutaud; Michael G Malkowski; Claus Schneider
Journal:  FASEB J       Date:  2018-08-10       Impact factor: 5.191

6.  Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.

Authors:  Hiroto Mitsui; Tomoki Aoyama; Moritoshi Furu; Kinya Ito; Yonghui Jin; Takayuki Maruyama; Toshiya Kanaji; Shinsei Fujimura; Hikaru Sugihara; Akio Nishiura; Takanobu Otsuka; Takashi Nakamura; Junya Toguchida
Journal:  Arthritis Res Ther       Date:  2011-09-14       Impact factor: 5.156

7.  Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein.

Authors:  Jinghua Jin; Feng-Shiun Shie; Jun Liu; Yan Wang; Jeanne Davis; Aimee M Schantz; Kathleen S Montine; Thomas J Montine; Jing Zhang
Journal:  J Neuroinflammation       Date:  2007-01-04       Impact factor: 8.322
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.