STUDY OBJECTIVES: To evaluate exercise testing for the assessment of the extent of pulmonary disease in patients with sarcoidosis. DESIGN: Retrospective analysis of consecutive patients with sarcoidosis referred to the Pulmonary Physiology Laboratory between 1992 and 1997, who completed at least 6 min of progressive bicycle exercise. Resting and exercise pulmonary function measurements were compared to radiographic stage of disease. SETTING: Pulmonary Physiology Laboratory at Washington, DC, Veterans Affairs Medical Center. PATIENTS: Forty-eight outpatient veterans with biopsy specimen-proven sarcoidosis. RESULTS: Across all radiographic stages of sarcoidosis, total lung capacity, resting diffusing capacity, and exercise gas exchange measurements had a significant variance with radiographic stage. Across the early radiographic stage disease (stages 0 to 2), the change in alveolar-arterial oxygen pressure gradient between rest and exercise, normalized for oxygen uptake, was the most significant measurement in its variation with radiographic stage. CONCLUSIONS: Changes in gas exchange with exercise may be the most sensitive physiologic measurements to assess the extent of disease in early radiographic stages of sarcoidosis.
STUDY OBJECTIVES: To evaluate exercise testing for the assessment of the extent of pulmonary disease in patients with sarcoidosis. DESIGN: Retrospective analysis of consecutive patients with sarcoidosis referred to the Pulmonary Physiology Laboratory between 1992 and 1997, who completed at least 6 min of progressive bicycle exercise. Resting and exercise pulmonary function measurements were compared to radiographic stage of disease. SETTING: Pulmonary Physiology Laboratory at Washington, DC, Veterans Affairs Medical Center. PATIENTS: Forty-eight outpatient veterans with biopsy specimen-proven sarcoidosis. RESULTS: Across all radiographic stages of sarcoidosis, total lung capacity, resting diffusing capacity, and exercise gas exchange measurements had a significant variance with radiographic stage. Across the early radiographic stage disease (stages 0 to 2), the change in alveolar-arterial oxygen pressure gradient between rest and exercise, normalized for oxygen uptake, was the most significant measurement in its variation with radiographic stage. CONCLUSIONS: Changes in gas exchange with exercise may be the most sensitive physiologic measurements to assess the extent of disease in early radiographic stages of sarcoidosis.
Authors: M A Spruit; M J Thomeer; R Gosselink; T Troosters; A Kasran; A J T Debrock; M G Demedts; M Decramer Journal: Thorax Date: 2005-01 Impact factor: 9.139
Authors: Agnaldo José Lopes; Sara Lucia Silveira de Menezes; Cristina Márcia Dias; Juliana Flávia de Oliveira; Míriam Raquel Meira Mainenti; Fernando Silva Guimarães Journal: Lung Date: 2011-08-20 Impact factor: 2.584
Authors: Marjolein Drent; Jolanda De Vries; Merinke Lenters; Rob J S Lamers; Snjezana Rothkranz-Kos; Emiel F M Wouters; Marja P van Dieijen-Visser; Johny A Verschakelen Journal: Eur Radiol Date: 2003-06-17 Impact factor: 5.315
Authors: Rik G J Marcellis; Antoine F Lenssen; Geeuwke J de Vries; Robert P Baughman; Chris P van der Grinten; Johny A Verschakelen; Jolanda De Vries; Marjolein Drent Journal: Lung Date: 2012-11-09 Impact factor: 2.584
Authors: A J Lopes; S L S Menezes; C M Dias; J F Oliveira; M R M Mainenti; F S Guimarães Journal: Braz J Med Biol Res Date: 2012-02-16 Impact factor: 2.590