Literature DB >> 1145181

Blockade of acetylcholine receptors: a model of myasthenia gravis.

S Satyamurti, D B Drachman, F Slone.   

Abstract

In order to block acetylcholine receptors of muscle, the alpha toxin of the Formosan cobra (Naja naja atra) was given intravenously to rats. Electrophysiological and pharmacological changes typical of myasthenia gravis were recorded, including decremental responses to repetitive stimuli, curare sensitivity, neostigmine reversal, and posttetanic phenomena. This model supports the concept that a reduction of available acetylcholine receptors may play an important role in myasthenia gravis.

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Year:  1975        PMID： 1145181     DOI： 10.1126/science.1145181

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

Review 1.  Immunopathologic events at the endplate in myasthenia gravis.

Authors:  T Ashizawa; S H Appel
Journal:  Springer Semin Immunopathol       Date:  1985

2.  Neuromuscular transmission in myasthenic single motor units.

Authors:  H A Kadrie; W F Brown
Journal:  J Neurol Neurosurg Psychiatry       Date:  1978-03       Impact factor: 10.154

3.  Abnormal pupillary responses in myasthenia gravis. A pupillographic study.

Authors:  A Yamazaki; S Ishikawa
Journal:  Br J Ophthalmol       Date:  1976-08       Impact factor: 4.638

Review 4.  Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases.

Authors:  Antony Rosen; Livia Casciola-Rosen
Journal:  Annu Rev Immunol       Date:  2016-02-22       Impact factor: 28.527

5.  Experimental autoimmune myasthenia gravis.

Authors:  J Lindstrom
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-07       Impact factor: 10.154

6.  Choline acetyltransferase activity in human muscular diseases.

Authors:  L Frattola; G Pezzoli; N Canal; M Trabucchi
Journal:  J Neurol       Date:  1976-01-14       Impact factor: 4.849

7.  [A transferable "Myasthenogenic" factor in the serum of patients with myasthenia gravis.].

Authors:  K V Toyka; D B Drachman; A Pestronk; K H Fischbeck; I Kao
Journal:  J Neurol       Date:  1976-06       Impact factor: 4.849

8.  [Myasthenic syndrome during penicillamine treatment (author's transl)].

Authors:  F Schumm; M Stöhr
Journal:  Klin Wochenschr       Date:  1978-02-01

9.  Mechanisms of acetylcholine receptor loss in myasthenia gravis.

Authors:  D B Drachman; R N Adams; E F Stanley; A Pestronk
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-07       Impact factor: 10.154

10.  Effect of myasthenic patients' immunoglobulin on acetylcholine receptor turnover: selectivity of degradation process.

Authors:  D B Drachman; C W Angus; R N Adams; I Kao
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205
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