Literature DB >> 11451589

Role of the activin-follistatin system in the morphogenesis and regeneration of the renal tubules.

I Kojima1, A Maeshima, Y Q Zhang.   

Abstract

Activin A inhibits branching tubulogenesis of the kidney during development. Activin A also inhibits branching tubulogenesis in MDCK cells, an in vitro tubulogenesis model. On the other hand, follistatin, an antagonist of activin A, reverses the effect of activin A and induces branching tubulogenesis. Follistatin also promotes tubular regeneration after ischemia/reperfusion injury. The activin/follistatin system is one of the important regulatory systems modulating developmental and regeneration processes of the kidney.

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Year:  2001        PMID： 11451589     DOI： 10.1016/s0303-7207(01)00511-1

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  5 in total

1.  GDF11 induces kidney fibrosis, renal cell epithelial-to-mesenchymal transition, and kidney dysfunction and failure.

Authors:  Marianne Pons; Leonidas G Koniaris; Sharon M Moe; Juan C Gutierrez; Aurora Esquela-Kerscher; Teresa A Zimmers
Journal:  Surgery       Date:  2018-05-03       Impact factor: 3.982

Review 2.  TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis.

Authors:  Kaoru Kahata; Varun Maturi; Aristidis Moustakas
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-03-01       Impact factor: 10.005

3.  Gene expression profiling reveals Cyp26b1 to be an activin regulated gene involved in ovarian granulosa cell proliferation.

Authors:  Jingjing L Kipp; Ann Golebiowski; Guadalupe Rodriguez; Michael Demczuk; Signe M Kilen; Kelly E Mayo
Journal:  Endocrinology       Date:  2010-11-17       Impact factor: 4.736

4.  Follistatin is a novel biomarker for lung adenocarcinoma in humans.

Authors:  Fangfang Chen; Ping Ren; Ye Feng; Haiyan Liu; Yang Sun; Zhonghui Liu; Jingyan Ge; Xueling Cui
Journal:  PLoS One       Date:  2014-10-27       Impact factor: 3.240

5.  Tissue absence initiates regeneration through follistatin-mediated inhibition of activin signaling.

Authors:  Michael A Gaviño; Danielle Wenemoser; Irving E Wang; Peter W Reddien
Journal:  Elife       Date:  2013-09-10       Impact factor: 8.140
  5 in total

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