OBJECTIVES: The purpose of this study was to evaluate the feasibility of measuring coronary flow velocity (CFV) by transthoracic Doppler echocardiography (TTDE) in the left anterior descending coronary artery (LAD) during contrast-enhanced dobutamine stress echocardiography (DSE). We also assessed the value of TTDE for detecting stress-induced myocardial ischemia in the LAD territory. BACKGROUND: Noninvasive assessment of both CFV and wall motion during DSE would enhance the diagnostic accuracy of DSE. METHODS: One hundred forty-four consecutive patients underwent CFV recording in the distal LAD by TTDE during contrast-enhanced DSE. Regional wall motion score index (WMSI) in the LAD territory and CFV ratio at peak stress (CFV ratio peak), defined as a ratio of CFV at peak stress to basal CFV, were obtained. RESULTS: Coronary flow velocity was successfully recorded in 129 patients (90%) at baseline and during dobutamine infusion. Mean value of CFV ratio peak was 2.39 +/- 0.83 (range: 0.84 to 4.40). There was good correlation between WMSI at peak stress and CFV ratio peak (r = 0.62, p < 0.001). Coronary flow velocity ratio peak was significantly lower in patients who developed stress-induced wall motion abnormality (WMA) in the LAD territory than it was in those patients without WMA (1.51 +/- 0.51 vs. 2.76 +/- 0.65, p < 0.001). A CFV ratio peak <2.1 had a sensitivity of 92% and a specificity of 86% for detecting the presence of stress-induced WMA. CONCLUSIONS: Assessment of CFV in the distal LAD during DSE is feasible in the majority of cases and provides a CFV ratio for detecting stress-induced myocardial ischemia in the LAD territory.
OBJECTIVES: The purpose of this study was to evaluate the feasibility of measuring coronary flow velocity (CFV) by transthoracic Doppler echocardiography (TTDE) in the left anterior descending coronary artery (LAD) during contrast-enhanced dobutamine stress echocardiography (DSE). We also assessed the value of TTDE for detecting stress-induced myocardial ischemia in the LAD territory. BACKGROUND: Noninvasive assessment of both CFV and wall motion during DSE would enhance the diagnostic accuracy of DSE. METHODS: One hundred forty-four consecutive patients underwent CFV recording in the distal LAD by TTDE during contrast-enhanced DSE. Regional wall motion score index (WMSI) in the LAD territory and CFV ratio at peak stress (CFV ratio peak), defined as a ratio of CFV at peak stress to basal CFV, were obtained. RESULTS: Coronary flow velocity was successfully recorded in 129 patients (90%) at baseline and during dobutamine infusion. Mean value of CFV ratio peak was 2.39 +/- 0.83 (range: 0.84 to 4.40). There was good correlation between WMSI at peak stress and CFV ratio peak (r = 0.62, p < 0.001). Coronary flow velocity ratio peak was significantly lower in patients who developed stress-induced wall motion abnormality (WMA) in the LAD territory than it was in those patients without WMA (1.51 +/- 0.51 vs. 2.76 +/- 0.65, p < 0.001). A CFV ratio peak <2.1 had a sensitivity of 92% and a specificity of 86% for detecting the presence of stress-induced WMA. CONCLUSIONS: Assessment of CFV in the distal LAD during DSE is feasible in the majority of cases and provides a CFV ratio for detecting stress-induced myocardial ischemia in the LAD territory.
Authors: Y Nohtomi; M Takeuchi; K Nagasawa; K Arimura; K Miyata; K Kuwata; T Yamawaki; S Kondo; A Yamada; S Okamatsu Journal: Heart Date: 2003-04 Impact factor: 5.994
Authors: José Sebastião de Abreu; José Wellington Oliveira Lima; Tereza Cristina Pinheiro Diógenes; Jordana Magalhães Siqueira; Nayara Lima Pimentel; Pedro Sabino Gomes Neto; Marília Esther Benevides de Abreu; José Nogueira Paes Júnior Journal: Arq Bras Cardiol Date: 2013-12-21 Impact factor: 2.000
Authors: José Sebastião de Abreu; Eduardo Arrais Rocha; Isadora Sucupira Machado; Isabelle O Parahyba; Thais Brito Rocha; Fernando José Villar Nogueira Paes; Tereza Cristina Pinheiro Diogenes; Marília Esther Benevides de Abreu; Ana Gardenia Liberato Ponte Farias; Marcia Maria Carneiro; José Nogueira Paes Journal: Arq Bras Cardiol Date: 2017-04-20 Impact factor: 2.000