Literature DB >> 11451198

Suppression of matrix metalloproteinase-2 and -9 mediated invasiveness by a novel matrix metalloproteinase inhibitor, BE16627B.

K Watanabe1, D Yoshida, M Noha, A Teramoto.   

Abstract

Cell invasion is a nature of malignant gliomas, demeriting to many efforts of the treatment. Matrix metalloproteinase (MMP) is acknowledged as a key factor in this complicated process. The aim of this study was to investigate whether inhibition of MMP activity in malignant glioma cells could be achieved by a novel agent, BE16627B (BE). Malignant glioma cell lines, U87MG, U251MG, and U373MG, were employed to evaluate inhibitory effect on zymogram, type IV collagenolysis assay, and haptoinvasion assay for 24 h exposure of BE, following preliminar

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Year:  2001        PMID： 11451198     DOI： 10.1023/a:1010639313832

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  26 in total

1.  C6 glioma-astrocytoma cell and fetal astrocyte migration into artificial basement membrane: a permissive substrate for neural tumors but not fetal astrocytes.

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Journal:  Neurosurgery       Date:  1991-05       Impact factor: 4.654

2.  Inhibition of collagenolytic activity relates to quantitative reduction of invasion in vitro in a c-Ha-ras transfected glial cell line.

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Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

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Journal:  Can J Neurol Sci       Date:  1987-02       Impact factor: 2.104

4.  Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

Authors:  J C Tonn; S Kerkau; A Hanke; H Bouterfa; J G Mueller; S Wagner; G H Vince; K Roosen
Journal:  Int J Cancer       Date:  1999-03-01       Impact factor: 7.396

5.  Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.

Authors:  E I Deryugina; M A Bourdon; R A Reisfeld; A Strongin
Journal:  Cancer Res       Date:  1998-08-15       Impact factor: 12.701

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Authors:  A Nakano; E Tani; K Miyazaki; Y Yamamoto; J Furuyama
Journal:  J Neurosurg       Date:  1995-08       Impact factor: 5.115

7.  Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors.

Authors:  J S Rao; P A Steck; S Mohanam; W G Stetler-Stevenson; L A Liotta; R Sawaya
Journal:  Cancer Res       Date:  1993-05-15       Impact factor: 12.701

8.  Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors.

Authors:  T Nakagawa; T Kubota; M Kabuto; K Sato; H Kawano; T Hayakawa; Y Okada
Journal:  J Neurosurg       Date:  1994-07       Impact factor: 5.115

9.  Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein.

Authors:  R D McComb; J M Moul; D D Bigner
Journal:  J Neuropathol Exp Neurol       Date:  1987-11       Impact factor: 3.685

10.  In vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate.

Authors:  D Yoshida; J M Piepmeier; A Teramoto
Journal:  Neurosurgery       Date:  1996-08       Impact factor: 4.654
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  5 in total

1.  Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.

Authors:  Maode Wang; Daizo Yoshida; Shouxun Liu; Akira Teramoto
Journal:  J Neurooncol       Date:  2005-03       Impact factor: 4.130

2.  Perturbation of hyaluronan interactions inhibits malignant properties of glioma cells.

Authors:  Jeanine A Ward; Lei Huang; Huiming Guo; Shibnath Ghatak; Bryan P Toole
Journal:  Am J Pathol       Date:  2003-05       Impact factor: 4.307

3.  Suppression of matrix metalloproteinase activity by SI-27: detection by a new activity assay with S-2444, a specific chromogenic peptide.

Authors:  Daizo Yoshida; Kunihiro Watanabe; Masahiro Noha; Hiroshi Takahashi; Akira Teramoto
Journal:  J Neurooncol       Date:  2002-05       Impact factor: 4.130

4.  Drug-induced apoptosis by a matrix metalloproteinase inhibitor, SI-27 on human malignant glioma cell lines; in vitro study.

Authors:  Ryuzaburo Kanazawa; Daizo Yoshida; Hiroshi Takahashi; Yuichi Sugisaki; Satoru Suzuki; Akira Teramoto
Journal:  J Neurooncol       Date:  2004-01       Impact factor: 4.130

5.  BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion.

Authors:  Mariano Sebastian Viapiano; Susan Hockfield; Russell Thomas Matthews
Journal:  J Neurooncol       Date:  2008-04-09       Impact factor: 4.130
  5 in total

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