G Slesak1, P C Döller. 1. Tropenklinik Paul-Lechler-Krankenhaus, Tübingen. guentherslesak@hotmail.com
Abstract
HISTORY AND CLINICAL FINDINGS: A 37-year-old German fell ill with fever and diffuse headaches 3 weeks after flying to Thailand for a holiday. Because of increasing sickness he began his return (13 h by train then 11 h by plane). Besides a temperature of 39.3 degrees C he presented with a unproductive cough and pain in his left calf. On examination there were no other pathological findings than a borderline tachycardia, mild hypotension and signs of dehydration. INVESTIGATIONS: Laboratory tests showed elevated inflammatory parameters (CRP 77.8 mg/l, ESR 36 mm), normal range of leucocytes with obvious shift to the left, mild thrombocytopenia and elevated liver enzymes. The Weil-Felix-reaction revealed a high antibody titre against OX 19, the IFT for Rickettsia typhi a significant increase of IgM with seroconversion for IgG. Duplex ultrasonography and phlebography confirmed a phlebothrombosis of the left upper thigh. DIAGNOSIS: Murine typhus and deep vein thrombosis of the left upper leg. TREATMENT AND COURSE: Suspecting typhoid fever with ciprofloxacin was started. In less then 2 days the patient became afebrile and recovered. The deep vein thrombosis was treated with low-molecular-weight heparin (Tinzaparin) overlapping with phenprocoumon. CONCLUSION: In patients with fever after travel to tropical or subtropical areas (including southern Europe) the diagnosis of murine typhus should be considered, especially if concomitant with thromboembolic events. The Weil-Felix-reaction is a helpful screening test supplemented by Rickettsia specific serologic tests. Overall a higher risk of thrombosis should be taken into account after long sedentary travel.
HISTORY AND CLINICAL FINDINGS: A 37-year-old German fell ill with fever and diffuse headaches 3 weeks after flying to Thailand for a holiday. Because of increasing sickness he began his return (13 h by train then 11 h by plane). Besides a temperature of 39.3 degrees C he presented with a unproductive cough and pain in his left calf. On examination there were no other pathological findings than a borderline tachycardia, mild hypotension and signs of dehydration. INVESTIGATIONS: Laboratory tests showed elevated inflammatory parameters (CRP 77.8 mg/l, ESR 36 mm), normal range of leucocytes with obvious shift to the left, mild thrombocytopenia and elevated liver enzymes. The Weil-Felix-reaction revealed a high antibody titre against OX 19, the IFT for Rickettsia typhi a significant increase of IgM with seroconversion for IgG. Duplex ultrasonography and phlebography confirmed a phlebothrombosis of the left upper thigh. DIAGNOSIS: Murine typhus and deep vein thrombosis of the left upper leg. TREATMENT AND COURSE: Suspecting typhoid fever with ciprofloxacin was started. In less then 2 days the patient became afebrile and recovered. The deep vein thrombosis was treated with low-molecular-weight heparin (Tinzaparin) overlapping with phenprocoumon. CONCLUSION: In patients with fever after travel to tropical or subtropical areas (including southern Europe) the diagnosis of murine typhus should be considered, especially if concomitant with thromboembolic events. The Weil-Felix-reaction is a helpful screening test supplemented by Rickettsia specific serologic tests. Overall a higher risk of thrombosis should be taken into account after long sedentary travel.