Literature DB >> 11448145

Protease-activated receptor-2 (PAR2) in the airways.

T M Cocks1, J D Moffatt.   

Abstract

Protease-activated receptors (PARs) act as sensors for active extracellular serine proteases. Since serine proteases like mast cell tryptase are associated with inflammatory processes, PARs may represent novel pharmacological targets in airway diseases like asthma and chronic obstructive pulmonary disease. However, our present understanding of the physiological roles of PARs is in its infancy. In this review we highlight evidence for the involvement of PARs in airway disease and propose that these novel receptors may play mainly protective roles. Copyright Academic Press.

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Year:  2001        PMID： 11448145     DOI： 10.1006/pupt.2001.0285

Source DB:  PubMed          Journal:  Pulm Pharmacol Ther        ISSN： 1094-5539            Impact factor:   3.410


  34 in total

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Review 2.  Innate immune responses to environmental allergens.

Authors:  Henk F Kauffman
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Review 3.  Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

Authors:  R Ramachandran; M D Hollenberg
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Review 4.  Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction.

Authors:  K Defea
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5.  CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

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Journal:  J Immunol       Date:  2015-06-03       Impact factor: 5.422

6.  A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance.

Authors:  Cara L Sherwood; Michael O Daines; Theodore J Price; Josef Vagner; Scott Boitano
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7.  2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice.

Authors:  Atsufumi Kawabata; Yuko Oono; Daiki Yonezawa; Kaori Hiramatsu; Naoki Inoi; Fumiko Sekiguchi; Masami Honjo; Michiko Hirofuchi; Toru Kanke; Hiroyuki Ishiwata
Journal:  Br J Pharmacol       Date:  2005-01       Impact factor: 8.739

8.  Proteinase-activated receptor 2 activation promotes an anti-inflammatory and alternatively activated phenotype in LPS-stimulated murine macrophages.

Authors:  Quan M Nhu; Kari Ann Shirey; Meghan E Pennini; Jennifer Stiltz; Stefanie N Vogel
Journal:  Innate Immun       Date:  2011-01-14       Impact factor: 2.680

9.  Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity.

Authors:  Prasad Rallabhandi; Quan M Nhu; Vladimir Y Toshchakov; Wenji Piao; Andrei E Medvedev; Morley D Hollenberg; Alessio Fasano; Stefanie N Vogel
Journal:  J Biol Chem       Date:  2008-07-11       Impact factor: 5.157

10.  Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.

Authors:  Ko-Wei Lin; Joungjoa Park; Anne L Crews; Yuehua Li; Kenneth B Adler
Journal:  Int J Biochem Cell Biol       Date:  2007-11-09       Impact factor: 5.085
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