Literature DB >> 11448057

The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma.

M Hagenaars1, R Koelemij, N G Ensink, J D van Eendenburg, R L van Vlierberghe, A M Eggermont, C J van de Velde, G J Fleuren, P J Kuppen.   

Abstract

In this paper we describe 4 new monoclonal antibodies to be applied in rat models for cancer. The monoclonal antibodies were obtained by immunizing Balb/c mice with CC531 rat colon adenocarcinoma cells. Hybridomas were produced and 4 were selected for their reactivity with CC531 in vitro (MG1, 2, 3 and 4). All 4 antibodies recognized other rat tumour cell lines and showed limited cross-reactivity with normal rat tissues. Intraperitoneally injected MG1, 2 and 4 homed to in vivo growing, artificially induced CC531 liver metastases. In these in vivo experiments, limited cross-reactivity with normal rat tissues, predominantly of the gastro-intestinal tract, was found. MG4 was found to enhance lysis of CC531 tumour cells mediated by IL-2 activated, cultured natural killer cells. These antibodies are potentially useful for antibody-based laboratory techniques and for investigation of antibody-based immunotherapy of cancer in a rat model.

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Year:  2000        PMID： 11448057     DOI： 10.1023/a:1011062002851

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  16 in total

Review 1.  Bispecific antibodies in cancer therapy, from the laboratory to the clinic.

Authors:  R Koelemij; P J Kuppen; C J van de Velde; G J Fleuren; M Hagenaars; A M Eggermont
Journal:  J Immunother       Date:  1999-11       Impact factor: 4.456

2.  Characterization of three new membrane structures on rat NK cells which are involved in activation of the lytic machinery.

Authors:  K M Giezeman-Smits; A Gorter; J F Nagelkerke; R L van Vlierberghe; J van Eendenburg; A M Eggermont; G J Fleuren; P J Kuppen
Journal:  Immunobiology       Date:  1997-11       Impact factor: 3.144

3.  Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration.

Authors:  M Hagenaars; N G Ensink; R Koelemij; P H Basse; A M Eggermont; C J van de Velde; G J Fleuren; P J Kuppen
Journal:  Int J Cancer       Date:  1998-01-19       Impact factor: 7.396

4.  The role of MHC class I expression in rat NK cell-mediated lysis of syngeneic tumor cells and virus-infected cells.

Authors:  K M Giezeman-Smits; P J Kuppen; N G Ensink; A M Eggermont; F Stals; K Wonigeit; G J Fleuren
Journal:  Immunobiology       Date:  1996-08       Impact factor: 3.144

Review 5.  Adjuvant therapy for resectable rectal and colonic cancer.

Authors:  A G Heriot; D Kumar
Journal:  Br J Surg       Date:  1998-03       Impact factor: 6.939

6.  Liver metastasis model of colon cancer in the rat: immunohistochemical characterization.

Authors:  C Thomas; A M Nijenhuis; W Timens; P J Kuppen; T Daemen; G L Scherphof
Journal:  Invasion Metastasis       Date:  1993

7.  The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats.

Authors:  P J Kuppen; P H Basse; R H Goldfarb; C J Van De Velde; G J Fleuren; A M Eggermont
Journal:  Int J Cancer       Date:  1994-02-15       Impact factor: 7.396

8.  Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group.

Authors:  G Riethmüller; E Schneider-Gädicke; G Schlimok; W Schmiegel; R Raab; K Höffken; R Gruber; H Pichlmaier; H Hirche; R Pichlmayr
Journal:  Lancet       Date:  1994-05-14       Impact factor: 79.321

9.  Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site.

Authors:  R L Marquet; D L Westbroek; J Jeekel
Journal:  Int J Cancer       Date:  1984-05-15       Impact factor: 7.396

10.  Increasing the effective concentration of melphalan in experimental rat liver tumours: comparison of isolated liver perfusion and hepatic artery infusion.

Authors:  A Marinelli; J H van Dierendonck; G M van Brakel; H Irth; P J Kuppen; U R Tjaden; C J van de Velde
Journal:  Br J Cancer       Date:  1991-12       Impact factor: 7.640
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  9 in total

1.  Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases.

Authors:  Sarah B White; Dong-Hyun Kim; Yang Guo; Weiguo Li; Yihe Yang; Jeane Chen; Venkateswara R Gogineni; Andrew C Larson
Journal:  Radiology       Date:  2017-07-13       Impact factor: 11.105

2.  Combination treatment of CC531-lac-Z rat liver metastases by chemoembolization with pemetrexed disodium and gemcitabine.

Authors:  Michael Rodenbach; Ergül Eyol; Matthias H Seelig; Martin R Berger
Journal:  J Cancer Res Clin Oncol       Date:  2005-01-19       Impact factor: 4.553

3.  Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis.

Authors:  Jurjen H L Velthuis; Miranda Stitzinger; Remco I J M Aalbers; Hans J G M de Bont; Gerard J Mulder; Peter J K Kuppen; J Fred Nagelkerke
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150

4.  Chemoembolization of rat liver metastasis with irinotecan and quantification of tumor cell reduction.

Authors:  Jan Saenger; Maike Leible; Matthias H Seelig; Martin R Berger
Journal:  J Cancer Res Clin Oncol       Date:  2004-01-22       Impact factor: 4.553

5.  Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels.

Authors:  W Ceelen; T Boterberg; P Smeets; N Van Damme; P Demetter; O Zwaenepoel; L Cesteleyn; P Houtmeyers; M Peeters; P Pattyn
Journal:  Br J Cancer       Date:  2007-02-13       Impact factor: 7.640

6.  Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.

Authors:  Sandra Heskamp; Linda Heijmen; Danny Gerrits; Janneke D M Molkenboer-Kuenen; Edwin G W Ter Voert; Kathrin Heinzmann; Davina J Honess; Donna-Michelle Smith; John R Griffiths; Sabrina Doblas; Ralph Sinkus; Peter Laverman; Wim J G Oyen; Arend Heerschap; Otto C Boerman
Journal:  Mol Imaging Biol       Date:  2017-08       Impact factor: 3.488

7.  Radioimmunotherapy improves survival of rats with microscopic liver metastases of colorectal origin.

Authors:  Gabie M de Jong; Thijs Hendriks; Annemarie Eek; Wim J G Oyen; Sandra Heskamp; Robert P Bleichrodt; Otto C Boerman
Journal:  Ann Surg Oncol       Date:  2009-05-09       Impact factor: 5.344

8.  A comparison between radioimmunotherapy and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis of colonic origin in rats.

Authors:  F Aarts; T Hendriks; O C Boerman; M J Koppe; W J G Oyen; R P Bleichrodt
Journal:  Ann Surg Oncol       Date:  2007-07-25       Impact factor: 5.344

9.  MHC class I expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway.

Authors:  Dianzhong Luo; David Vermijlen; Peter JK Kuppen; Eddie Wisse
Journal:  Comp Hepatol       Date:  2002-11-20
  9 in total

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