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Literature DB >> 11447203

Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia.

N P Juffermans¹, P E Dekkers, A Verbon, P Speelman, S J van Deventer, T van der Poll.

Abstract

Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2001 PMID： 11447203 PMCID： PMC98617 DOI： 10.1128/IAI.69.8.5182-5185.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

Review 1. uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?

Authors: F Blasi
Journal: Immunol Today Date: 1997-09

2. Nonopsonic and opsonic association of Mycobacterium tuberculosis with resident alveolar macrophages is inefficient.

Authors: R W Stokes; L M Thorson; D P Speert
Journal: J Immunol Date: 1998-06-01 Impact factor: 5.422

3. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells.

Authors: D I Simon; N K Rao; H Xu; Y Wei; O Majdic; E Ronne; L Kobzik; H A Chapman
Journal: Blood Date: 1996-10-15 Impact factor: 22.113

4. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes.

Authors: R G Sitrin; R F Todd; E Albrecht; M R Gyetko
Journal: J Clin Invest Date: 1996-04-15 Impact factor: 14.808

5. Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFN-gamma activation inhibits complement receptor function and phagocytosis of this bacterium.

Authors: L S Schlesinger; M A Horwitz
Journal: J Immunol Date: 1991-09-15 Impact factor: 5.422

6. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia.

Authors: P E Dekkers; T ten Hove; A A te Velde; S J van Deventer; T van Der Poll
Journal: Infect Immun Date: 2000-04 Impact factor: 3.441

7. Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.

Authors: N P Juffermans; A Verbon; S J van Deventer; H van Deutekom; J T Belisle; M E Ellis; P Speelman; T van der Poll
Journal: Infect Immun Date: 1999-08 Impact factor: 3.441

8. Increased production of hydrogen peroxide and expression of CD11b/CD18 on alveolar macrophages in patients with active pulmonary tuberculosis.

Authors: H P Kuo; T C Ho; C H Wang; C T Yu; H C Lin
Journal: Tuber Lung Dis Date: 1996-10

7. The blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathway.

Authors: Yosuke Kanno; Akira Ishisaki; Mei Miyashita; Osamu Matsuo
Journal: Immun Inflamm Dis Date: 2016-08-02

7 in total

Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia.

Review 1. uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?

2. Nonopsonic and opsonic association of Mycobacterium tuberculosis with resident alveolar macrophages is inefficient.

3. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells.

4. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes.

5. Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFN-gamma activation inhibits complement receptor function and phagocytosis of this bacterium.

6. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia.

7. Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.

8. Increased production of hydrogen peroxide and expression of CD11b/CD18 on alveolar macrophages in patients with active pulmonary tuberculosis.

9. Function of the urokinase receptor (CD87) in neutrophil chemotaxis.

10. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

1. Serum Levels of Soluble Urokinase Plasminogen Activator Receptor in Infants with Late-onset Sepsis.

Review 2. C-type lectin receptors in tuberculosis: what we know.

3. Participation of the urokinase receptor in neutrophil efferocytosis.

4. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.

5. Utility of the plasma level of suPAR in monitoring risk of mortality during TB treatment.

Review 6. suPAR as a prognostic biomarker in sepsis.

7. The blocking of uPAR suppresses lipopolysaccharide-induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathway.