Literature DB >> 11446535

Aspergillus fumigatus CYP51 sequence: potential basis for fluconazole resistance.

T D Edlind1, K W Henry, K A Metera, S K Katiyar.   

Abstract

We have cloned and sequenced the Aspergillus fumigatus CYP51 gene which encodes the target of azole antifungal agents, namely cytochrome P450 sterol 14alpha-demethylase. Since A. fumigatus is intrinsically resistant to the widely used azole fluconazole, we compared its predicted CYP51 sequence to the CYP51 sequences from fluconazole-susceptible and resistant Candida albicans. This analysis generated specific hypotheses regarding the basis for A. fumigatus fluconazole resistance; in particular, A. fumigatus residue Ile301 corresponds to C. albicans residue Thr315 which is mutated to Ala in resistant strains and is proposed to hydrogen bond with the sterol substrate.

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Year:  2001        PMID： 11446535     DOI： 10.1080/mmy.39.3.299.302

Source DB:  PubMed          Journal:  Med Mycol        ISSN： 1369-3786            Impact factor:   4.076


  11 in total

Review 1.  Mechanisms of fungal resistance: an overview.

Authors:  Maher M Balkis; Steven D Leidich; Pranab K Mukherjee; Mahmoud A Ghannoum
Journal:  Drugs       Date:  2002       Impact factor: 9.546

2.  Azole drug import into the pathogenic fungus Aspergillus fumigatus.

Authors:  Brooke D Esquivel; Adam R Smith; Martin Zavrel; Theodore C White
Journal:  Antimicrob Agents Chemother       Date:  2015-03-30       Impact factor: 5.191

3.  A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus.

Authors:  T M Diaz-Guerra; E Mellado; M Cuenca-Estrella; J L Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

Review 4.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

5.  Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.

Authors:  Paul A Mann; Raulo M Parmegiani; Shui-Qing Wei; Cara A Mendrick; Xin Li; David Loebenberg; Beth DiDomenico; Roberta S Hare; Scott S Walker; Paul M McNicholas
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

6.  Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Authors:  Alia A Sagatova; Mikhail V Keniya; Rajni K Wilson; Brian C Monk; Joel D A Tyndall
Journal:  Antimicrob Agents Chemother       Date:  2015-06-08       Impact factor: 5.191

7.  Aspergillus fumigatus Intrinsic Fluconazole Resistance Is Due to the Naturally Occurring T301I Substitution in Cyp51Ap.

Authors:  Florencia Leonardelli; Daiana Macedo; Catiana Dudiuk; Matias S Cabeza; Soledad Gamarra; Guillermo Garcia-Effron
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

Review 8.  Emergence of Triazole Resistance in Aspergillus spp. in Latin America.

Authors:  Daiana Macedo; Florencia Leonardelli; Soledad Gamarra; Guillermo Garcia-Effron
Journal:  Curr Fungal Infect Rep       Date:  2021-05-19

9.  Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz.

Authors:  Tingfu Zhang; Qianwen Cao; Na Li; Deli Liu; Yongze Yuan
Journal:  BMC Genomics       Date:  2020-02-12       Impact factor: 3.969

10.  Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase.

Authors:  Rita Caramalho; Joel D A Tyndall; Brian C Monk; Thomas Larentis; Cornelia Lass-Flörl; Michaela Lackner
Journal:  Sci Rep       Date:  2017-11-21       Impact factor: 4.379
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