Literature DB >> 11445833

Reduced glutathione system: role in cancer development, prevention and treatment (review).

R Locigno1, V Castronovo.   

Abstract

Reduced glutathione (GSH), a ubiquitous thiol-containing tripeptide, is unanimously recognized to play a central role in cell biology. It is highly implicated in the cellular defense against xenobiotics and naturally occurring deleterious compounds such as free radicals and hydroperoxides. Consequently, GSH is an essential actor in several human diseases including cancer and cardio-vascular diseases. Its implication in oncogenesis has led to the development of new strategies to improve both prevention and treatment of cancer. The present review proposes an in depth analysis or our current knowledge of the relations between GSH and cancer.

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Year:  2001        PMID： 11445833     DOI： 10.3892/ijo.19.2.221

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  14 in total

1.  Chronic unpredictable stress (CUS) enhances the carcinogenic potential of 7,12-dimethylbenz(a)anthracene (DMBA) and accelerates the onset of tumor development in Swiss albino mice.

Authors:  Nida Suhail; Nayeem Bilal; Shirin Hasan; Ausaf Ahmad; Ghulam Md Ashraf; Naheed Banu
Journal:  Cell Stress Chaperones       Date:  2015-08-14       Impact factor: 3.667

2.  Altered glutamate cysteine ligase expression and activity in renal cell carcinoma.

Authors:  Monong Li; Zongliang Zhang; Jiangshui Yuan; Yanlun Zhang; Xunbo Jin
Journal:  Biomed Rep       Date:  2014-09-09

Review 3.  Oxidative stress and diabetic kidney disease.

Authors:  Robert C Stanton
Journal:  Curr Diab Rep       Date:  2011-08       Impact factor: 4.810

4.  Chronic unpredictable stress exacerbates 7,12-dimethylbenz (a) anthracene induced hepatotoxicity and nephrotoxicity in Swiss albino mice.

Authors:  Nida Suhail; Nayeem Bilal; Shirin Hasan; Naheed Banu
Journal:  Mol Cell Biochem       Date:  2011-05-01       Impact factor: 3.396

5.  Utilization of glutamate/creatine ratios for proton spectroscopic diagnosis of meningiomas.

Authors:  Saman Hazany; John R Hesselink; John F Healy; Steven G Imbesi
Journal:  Neuroradiology       Date:  2006-11-04       Impact factor: 2.804

6.  Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population.

Authors:  Yujue Wang; Lian Zhang; Roxana Moslehi; Junling Ma; Kaifeng Pan; Tong Zhou; Weidong Liu; Linda Morris Brown; Yuangreng Hu; David Pee; Mitchell H Gail; Weicheng You
Journal:  J Nutr       Date:  2008-12-03       Impact factor: 4.798

7.  Blood iron, glutathione, and micronutrient levels and the risk of oral cancer.

Authors:  John P Richie; Wayne Kleinman; Patricia Marina; Patricia Abraham; Ernst L Wynder; Joshua E Muscat
Journal:  Nutr Cancer       Date:  2008       Impact factor: 2.900

8.  Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients.

Authors:  Ondrej Zitka; Sylvie Skalickova; Jaromir Gumulec; Michal Masarik; Vojtech Adam; Jaromir Hubalek; Libuse Trnkova; Jarmila Kruseova; Tomas Eckschlager; Rene Kizek
Journal:  Oncol Lett       Date:  2012-09-21       Impact factor: 2.967

9.  Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice.

Authors:  Kun-Ming Chen; Todd D Schell; John P Richie; Yuan-Wan Sun; Shang-Min Zhang; Ana Calcagnotto; Cesar Aliaga; Krishne Gowda; Shantu Amin; Karam El-Bayoumy
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2017-12-04       Impact factor: 3.781

10.  Protective effect of theaflavin on erythrocytes subjected to in vitro oxidative stress.

Authors:  Mahejabeen Fatima; Rajesh Kumar Kesharwani; Krishna Misra; Syed Ibrahim Rizvi
Journal:  Biochem Res Int       Date:  2013-12-21
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