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Literature DB >> 11445535

The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor.

A Prokhortchouk¹, B Hendrich, H Jørgensen, A Ruzov, M Wilm, G Georgiev, A Bird, E Prokhortchouk.

Abstract

We describe a novel mammalian DNA binding activity that requires at least two symmetrically methylated CpG dinucleotides in its recognition sequence, preferably within the sequence 5'CGCG. A key component of the activity is Kaiso, a protein with POZ and zinc-finger domains that is known to associate with p120 catenin. We find that Kaiso behaves as a methylation-dependent transcriptional repressor in transient transfection assays. Kaiso is a constituent of one of two methyl-CpG binding complexes originally designated as MeCP1. The data suggest that zinc-finger motifs are responsible for DNA binding, and may therefore target repression to specific methylated regions of the genome. As Kaiso associates with p120 catenin, Kaiso may link events at the cell surface with DNA methylation-dependent gene silencing.

Entities: Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11445535 PMCID： PMC312733 DOI： 10.1101/gad.198501

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

31 in total

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Journal: J Biol Chem Date: 2000-01-28 Impact factor: 5.157

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Authors: I Stancheva; R R Meehan
Journal: Genes Dev Date: 2000-02-01 Impact factor: 11.361

10. The p120 catenin family: complex roles in adhesion, signaling and cancer.

Authors: P Z Anastasiadis; A B Reynolds
Journal: J Cell Sci Date: 2000-04 Impact factor: 5.285

172 in total

1. The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.

Authors: Juliet M Daniel; Christopher M Spring; Howard C Crawford; Albert B Reynolds; Akeel Baig
Journal: Nucleic Acids Res Date: 2002-07-01 Impact factor: 16.971

2. Tissue-specific silencing of a transgene in rice.

Authors: A Klöti; X He; I Potrykus; T Hohn; J Fütterer
Journal: Proc Natl Acad Sci U S A Date: 2002-07-19 Impact factor: 11.205

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Authors: Masayuki Sekimata; Yoshimi Homma
Journal: Nucleic Acids Res Date: 2004-01-29 Impact factor: 16.971

Review 4. Rett syndrome and MeCP2: linking epigenetics and neuronal function.

Authors: Mona D Shahbazian; Huda Y Zoghbi
Journal: Am J Hum Genet Date: 2002-11-19 Impact factor: 11.025

Review 5. CpG methylation in neurons: message, memory, or mask?

Authors: Rajiv P Sharma; David P Gavin; Dennis R Grayson
Journal: Neuropsychopharmacology Date: 2010-07-14 Impact factor: 7.853

Review 6. The catenin family at a glance.

Authors: Pierre D McCrea; Dongmin Gu
Journal: J Cell Sci Date: 2010-03-01 Impact factor: 5.285

7. Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl-CpG DNA targets.

Authors: Bethany A Buck-Koehntop; Maria A Martinez-Yamout; H Jane Dyson; Peter E Wright
Journal: FEBS Lett Date: 2012-01-30 Impact factor: 4.124