| Literature DB >> 11443729 |
K S Hendrich1, P M Kochanek, J A Melick, J K Schiding, K D Statler, D S Williams, D W Marion, C Ho.
Abstract
The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5-3 times lower in most regions analyzed during anesthesia with either fentanyl (with N(2)O/O(2)) or pentobarbital vs. isoflurane (with N(2)O/O(2)), in agreement with findings utilizing invasive measurement techniques. CBF was heterogeneous in rats anesthetized with isoflurane (with N(2)O/O(2)), but relatively homogeneous in rats anesthetized with either fentanyl (with N(2)O/O(2)) or pentobarbital, also in agreement with studies using other techniques. Magn Reson Med 46:202-206, 2001. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2001 PMID： 11443729 DOI： 10.1002/mrm.1178
Source DB: PubMed Journal: Magn Reson Med ISSN： 0740-3194 Impact factor: 4.668