| Literature DB >> 11443226 |
U Bachrach1, Y C Wang, A Tabib.
Abstract
The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).Entities:
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Year: 2001 PMID： 11443226 DOI： 10.1152/physiologyonline.2001.16.3.106
Source DB: PubMed Journal: News Physiol Sci ISSN： 0886-1714