| Literature DB >> 11442897 |
H C Liu1, C J Hong, C Y Liu, K N Lin, S J Tsai, T Y Liu, C W Chi, P N Wang.
Abstract
A significant increase of 267C allele of the 5-HT(6) receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT(6) genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.Entities:
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Year: 2001 PMID： 11442897 DOI： 10.1046/j.1440-1819.2001.00886.x
Source DB: PubMed Journal: Psychiatry Clin Neurosci ISSN： 1323-1316 Impact factor: 5.188