BACKGROUND: Perineural invasion is an important mode of tumor spread and is associated with increased aggressiveness and a propensity for recurrence among cutaneous malignancies. OBJECTIVE: To review the pathogenesis, diagnosis, and treatment of cutaneous tumors exhibiting perineural invasion. METHODS: This article is based on a review of the medical literature concerning tumors with perineural involvement. RESULTS: This article describes the clinical signs and histologic features of cutaneous malignancies exhibiting perineural involvement. CONCLUSION: Appropriate patient care mandates consideration of perineural invasion in the evaluation of cutaneous tumors. As the majority of patients present without symptoms of neural involvement, physicians must be vigilant in the search for this type of tumor spread.
BACKGROUND: Perineural invasion is an important mode of tumor spread and is associated with increased aggressiveness and a propensity for recurrence among cutaneous malignancies. OBJECTIVE: To review the pathogenesis, diagnosis, and treatment of cutaneous tumors exhibiting perineural invasion. METHODS: This article is based on a review of the medical literature concerning tumors with perineural involvement. RESULTS: This article describes the clinical signs and histologic features of cutaneous malignancies exhibiting perineural involvement. CONCLUSION: Appropriate patient care mandates consideration of perineural invasion in the evaluation of cutaneous tumors. As the majority of patients present without symptoms of neural involvement, physicians must be vigilant in the search for this type of tumor spread.
Authors: Michael A Gorin; Heather J Chalfin; Jonathan I Epstein; Zhaoyong Feng; Alan W Partin; Bruce J Trock Journal: Urology Date: 2014-03-19 Impact factor: 2.649
Authors: Sharifeh Farasat; Siegrid S Yu; Victor A Neel; Kishwer S Nehal; Thomas Lardaro; Martin C Mihm; David R Byrd; Charles M Balch; Joseph A Califano; Alice Y Chuang; William H Sharfman; Jatin P Shah; Paul Nghiem; Clark C Otley; Anthony P Tufaro; Timothy M Johnson; Arthur J Sober; Nanette J Liégeois Journal: J Am Acad Dermatol Date: 2011-01-20 Impact factor: 11.527
Authors: Evi M Morandi; Tina Rauchenwald; Petra Puelzl; Bernhard W Zelger; Bettina G Zelger; Benjamin Henninger; Gerhard Pierer; Dolores Wolfram Journal: J Dtsch Dermatol Ges Date: 2021-11 Impact factor: 5.231