Inflammation and writhing syndrome inducing effect of PGE1, PGE2 and the inhibition of these actions.

The inflammatory and nociception inducing effect of PGE1 and PGE2, and the inhibition of these actions were studied. The inflammatory effect was produced in rat paw by intradermal injection of PG. Both PGE1 and PGE2 in doses of 500 ng produced maximal inflammatory and vascular permeability increasing effects. With higher doses these responses decreased. Antiserotonin, antihistamine drugs partly antagonized the above mentioned effects of PG.