| Literature DB >> 11440584 |
R E Taylor1, Y Chen.
Abstract
[reaction: see text] A highly convergent total synthesis of the natural products epothilone B and D is described. The route is highlighted by efficient generation of a C12-C13 trisubstituted olefin which exploits a sequential Nozaki-Hiyama-Kishi coupling and a stereoselective thionyl chloride rearrangement.Entities:
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Year: 2001 PMID： 11440584 DOI： 10.1021/ol010094x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005