BACKGROUND: Respiratory disease is the major cause of morbidity and mortality in cystic fibrosis (CF). The significance of Burkholderia cepacia (B. cepacia) in the pathogenesis of lung disease in CF is debated, but its exact role remains unclear. AIM: To assess the impact of respiratory tract colonisation with B. cepacia in patients with CF by measuring changes in pulmonary function and body mass index (BMI). METHODS: Three groups of patients were defined based on sputum culture isolates: Group 1 were B. cepacia and Pseudomonas aeruginosa (P. aeruginosa) positive patients; Group 2 were P. aeruginosa positive; and Group 3 were colonised with neither organism. Forced expiratory volume (FEV) and BMI were measured annually from 1987 to 1995 and the year of acquisition of P. aeruginosa or B. cepacia was recorded. RESULTS: The mean annual decrease in FEV1 was significantly different in all three groups: Group 1, -5.4 (5.1)%; Group 2, -3.9 (6.5)%; and Group 3, -1.6 (1.0)%, (p<0.05). The mean percentage decrease in FEV1 of a sub-group of Group 1 patients where the B. cepacia acquisition date was known was 6.1% per year versus 1.55% in Group 2 patients (p<0.05). CONCLUSIONS: Acquisition of B. cepacia may be a cause of, rather than a marker for, a decrease in pulmonary function.
BACKGROUND: Respiratory disease is the major cause of morbidity and mortality in cystic fibrosis (CF). The significance of Burkholderia cepacia (B. cepacia) in the pathogenesis of lung disease in CF is debated, but its exact role remains unclear. AIM: To assess the impact of respiratory tract colonisation with B. cepacia in patients with CF by measuring changes in pulmonary function and body mass index (BMI). METHODS: Three groups of patients were defined based on sputum culture isolates: Group 1 were B. cepacia and Pseudomonas aeruginosa (P. aeruginosa) positive patients; Group 2 were P. aeruginosa positive; and Group 3 were colonised with neither organism. Forced expiratory volume (FEV) and BMI were measured annually from 1987 to 1995 and the year of acquisition of P. aeruginosa or B. cepacia was recorded. RESULTS: The mean annual decrease in FEV1 was significantly different in all three groups: Group 1, -5.4 (5.1)%; Group 2, -3.9 (6.5)%; and Group 3, -1.6 (1.0)%, (p<0.05). The mean percentage decrease in FEV1 of a sub-group of Group 1 patients where the B. cepacia acquisition date was known was 6.1% per year versus 1.55% in Group 2 patients (p<0.05). CONCLUSIONS: Acquisition of B. cepacia may be a cause of, rather than a marker for, a decrease in pulmonary function.
Authors: O C Tablan; T L Chorba; D V Schidlow; J W White; K A Hardy; P H Gilligan; W M Morgan; L A Carson; W J Martone; J M Jason Journal: J Pediatr Date: 1985-09 Impact factor: 4.406
Authors: S Häussler; C Lehmann; C Breselge; M Rohde; M Classen; B Tümmler; P Vandamme; I Steinmetz Journal: Eur J Clin Microbiol Infect Dis Date: 2003-03-28 Impact factor: 3.267
Authors: Basant A Abdulrahman; Arwa Abu Khweek; Anwari Akhter; Kyle Caution; Mia Tazi; Hoda Hassan; Yucheng Zhang; Patrick D Rowland; Sankalp Malhotra; Famke Aeffner; Ian C Davis; Miguel A Valvano; Amal O Amer Journal: J Biol Chem Date: 2012-11-12 Impact factor: 5.157
Authors: Basant A Abdulrahman; Arwa Abu Khweek; Anwari Akhter; Kyle Caution; Sheetal Kotrange; Dalia H A Abdelaziz; Christie Newland; Roberto Rosales-Reyes; Benjamin Kopp; Karen McCoy; Richard Montione; Larry S Schlesinger; Mikhail A Gavrilin; Mark D Wewers; Miguel A Valvano; Amal O Amer Journal: Autophagy Date: 2011-11-01 Impact factor: 16.016
Authors: Andrew I Perault; Courtney E Chandler; David A Rasko; Robert K Ernst; Matthew C Wolfgang; Peggy A Cotter Journal: Cell Host Microbe Date: 2020-08-04 Impact factor: 21.023
Authors: Vidya P Narayanaswamy; Scott Giatpaiboon; Shenda M Baker; William P Wiesmann; John J LiPuma; Stacy M Townsend Journal: PLoS One Date: 2017-06-29 Impact factor: 3.240
Authors: Matthew M Schaefers; Tiffany L Liao; Nicole M Boisvert; Damien Roux; Deborah Yoder-Himes; Gregory P Priebe Journal: PLoS Pathog Date: 2017-01-03 Impact factor: 6.823